Publications by authors named "G Helft"
Epidemiology of cardiovascular risk factors: Behavioural risk factors.
Arch Cardiovasc Dis
December 2024
Article Synopsis
- * A significant portion of the French population engages in unhealthy behaviors: one-third smoke, 71.7% don’t consume enough fruits and vegetables, and many fail to meet physical activity guidelines.
- * Although there are some improvements, like increased physical activity in men and reduced smoking rates, serious concerns remain, especially as women's health behaviors begin to mirror those of men, highlighting the need for enhanced prevention efforts.
Background And Objectives: The risk profiles, procedural characteristics, and clinical outcomes for women undergoing bifurcation percutaneous coronary intervention (PCI) are not well defined compared to those in men.
Methods: COronary BIfurcation Stenting III (COBIS III) is a multicenter, real-world registry of 2,648 patients with bifurcation lesions treated with second-generation drug-eluting stents. We compared the angiographic and procedural characteristics and clinical outcomes based on sex.
Epidemiology of cardiovascular risk factors: Non-behavioural risk factors.
Arch Cardiovasc Dis
December 2024
Article Synopsis
- Cardiovascular disease is the leading cause of death globally and a major concern in France, heavily influenced by modifiable risk factors like obesity, diabetes, hypertension, and high cholesterol levels.
- In 2015, significant prevalence rates for these conditions were reported among adults aged 18-74, with obesity at 17.2% and diabetes at 7.4%, yet awareness of these conditions was low among those affected.
- A push for better prevention methods, especially through nutrition and education, is essential to tackle these cardiovascular risk factors, with a noted importance on also addressing women's specific health issues that impact cardiovascular risk.
The host-microbiota co-metabolite trimethylamine N-oxide (TMAO) is linked to increased cardiovascular risk but how its circulating levels are regulated remains unclear. We applied "explainable" machine learning, univariate, multivariate and mediation analyses of fasting plasma TMAO concentration and a multitude of phenotypes in 1,741 adult Europeans of the MetaCardis study. Here we show that next to age, kidney function is the primary variable predicting circulating TMAO, with microbiota composition and diet playing minor, albeit significant, roles.
View Article and Find Full Text PDFBackground: Although Medina 0.0.1 bifurcation lesions are often treated by percutaneous coronary intervention (PCI) in real-world practice, the optimal revascularization strategy for this lesion is uncertain.
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