Publications by authors named "G Heinicke"
Article Synopsis
- A 54-year-old woman with asthma and a history of smoking was evaluated for pulmonary nodules found on a CT scan.
- The dominant nodule in her left upper lobe was sampled using a robotic-assisted bronchoscope, which provided a safe way to obtain a biopsy.
- The results supported a diagnosis of Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia (DIPNECH), a rare condition that showcases the advantages of modern navigational bronchoscopy over traditional biopsy methods.
Drug-layered sugar spheres 15, 45, and 64% potent were made such that each had the same particle size distribution. The particles were coated to the same coat thickness with an ammonio polymethacrylate formulation, and drug release was measured in two media. The products exhibited a sigmoidal release pattern, where a lag time was followed by relatively rapid drug release.
View Article and Find Full Text PDFA cationic polymethacrylate coated multiparticulate diltiazem formulation exhibited sigmoidal drug release. Lag time prior to drug release was influenced by dissolution media, coat thickness, and by the nature of additives included in the formulation. Incorporation of up to 5% w/w sodium lauryl sulfate (SLS) in the coating membrane resulted in substantial increases in lag times in acidic and neutral media.
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