Publications by authors named "G Haynatzki"
Background: Sex inequality in randomized controlled trials (RCTs) related to cardiovascular disease has been observed. This study examined the proportion of women enrolled in atrial fibrillation (AF) ablation RCTs and the potential risks of underrepresentation of women.
Methods And Results: We systematically searched PubMed and Embase for AF ablation RCTs published from 2015 to 2022.
Background: Farm operators are at a high risk of developing skin cancer due to their occupational sun exposure. With the growing incidence of skin cancer, it is also important to evaluate other occupational risk factors. Farm operators confront numerous physical, chemical, and biological hazards in their work environment.
View Article and Find Full Text PDFArticle Synopsis
- Peripheral artery disease (PAD) leads to muscle damage linked to mitochondrial dysfunction, and the study aims to understand how alcohol and a high-fat diet affect this condition in a mouse model.
- Mice were placed on high-fat-sucrose (HFS) or low-fat-sucrose (LFS) diets and given ethanol to analyze its impact on oxidative stress and mitochondrial health after inducing limb ischemia.
- Findings revealed that high-fat and alcohol consumption worsened mitochondrial issues in muscles, with reduced levels of the enzyme ALDH2 correlating with increased oxidative stress, suggesting ALDH2 may be a therapeutic target for PAD patients with unhealthy diets.
Peripheral artery disease (PAD) is an atherosclerotic condition that impairs blood flow to the lower extremities, resulting in myopathy in affected skeletal muscles. Improving our understanding of PAD and developing novel treatment strategies necessitates a comprehensive examination of cellular structural alterations that occur in the muscles with disease progression. Here we aimed to employ electron microscopy to quantify skeletal muscle ultrastructural alterations responsible for the myopathy of PAD.
View Article and Find Full Text PDFRepresentation of obesity in contemporary atrial fibrillation ablation randomized controlled trials.
J Cardiovasc Electrophysiol
October 2024
Background: The prevalence and impact of obesity on outcomes of atrial fibrillation (AF) ablation randomized controlled trials (RCTs) have not been well studied.
Objective: To examine the proportion of participants with obesity enrolled in RCTs of AF ablation and outcomes of ablation when subgroup analysis of participants with obesity were available.
Methods: We systematically searched PubMed and EMBASE for AF ablation RCTs published between January 1, 2015 to May 31, 2022.