Publications by authors named "G Hatch"
Article Synopsis
- B lymphocyte activation leads to changes in metabolism that are crucial for their development and immune response, specifically regarding the enzyme hexokinase 2 (HK2).
- The study finds that the PI3K signaling pathway regulates both the expression and location of HK2 in B cells, affecting their function and glucose dependence.
- Mice lacking HK2 show impaired immune responses after immunization, indicating that HK2 is critical for B cell function and can also influence leukemia cell proliferation through PI3K pathways.
The relation between testosterone replacement therapy (TRT) and anterior cruciate ligament injury risk has garnered attention in recent orthopaedic research. With TRT's popularity on the rise, understanding its potential musculoskeletal risks is important for orthopaedic and sports medicine providers. Whereas some studies suggest an association, confounding variables such as activity level, number of hours of sports participation, dosing variations, physiological versus supraphysiological levels of testosterone, and individual patient characteristics may influence outcomes.
View Article and Find Full Text PDFAim: Barth syndrome (BTHS) is a rare X-linked genetic disease in which mitochondrial oxidative phosphorylation is impaired due to a mutation in the gene. The protein kinase C delta (PKCδ) signalosome exists as a high molecular weight complex in mitochondria and controls mitochondrial oxidative phosphorylation.
Method: Here, we examined PKCδ levels in mitochondria of aged-matched control and BTHS patient B lymphoblasts and its association with a higher molecular weight complex in mitochondria.