Publications by authors named "G Hartel"
Background: Scabies is a debilitating and neglected infectious disease with limited effective treatment options and affecting millions of people worldwide, mainly in poor and overcrowded settings. Essential oils from Australasian Myrtaceae are known to have parasiticidal properties, often attributed to the presence of β-triketones, which are known inhibitors of the tyrosine catabolism pathway through inhibition of hydroxyphenylpyruvate dioxygenase (HPPD).
Purpose: In this study, essential oils from mānuka (Leptospermum scoparium) were evaluated in vitro for miticidal and ovicidal activities and their active β-triketone constituents (flavesone, leptospermone, and isoleptospermone) were identified.
Article Synopsis
- The study investigates how pre-pregnancy obesity may increase the risk of preterm birth by examining metabolites, Flt3L levels, and proinflammatory cytokine profiles in pregnant women.
- Researchers analyzed blood samples from 124 women in Australia, finding that mothers who gave birth preterm had lower Flt3L and higher IL-6 levels compared to those who delivered at term.
- The findings indicate that maternal obesity alters metabolite levels and reduces Flt3L expression, which could contribute to the increased risk of preterm births among obese mothers.
Introduction: Routine collection of patient-reported outcome measures (PROMs) has the potential to inform and improve cancer care. It is now feasible for patients to complete PROMs electronically (ePROMs) providing information about their current levels of symptoms, side effects of treatment and other concerns. PROM scores can be tracked over time allowing more timely identification of problems and more appropriate intervention.
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- Colorectal cancer is a leading cause of cancer deaths in Australia, and colonoscopy and polypectomy are effective preventive measures.
- The study examined risk factors, particularly focusing on metabolic conditions and BMI, in 357 individuals aged 20-85 referred for colonoscopy.
- Findings indicate a significant link between elevated BMI and colorectal neoplasia, highlighting the need for public health initiatives targeting diet and weight management in an overweight population.