Publications by authors named "G Harry Van Lenthe"

HR-pQCT has become standard practice when quantifying volumetric BMD (vBMD) in vivo. Yet, it is only accessible to peripheral sites, with small fields of view and lengthy scanning times. This limits general applicability in clinical workflows.

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Article Synopsis
  • - The study addresses the need for reliable methods to predict the risk of fractures in patients with femoral metastases, highlighting the limitations of current clinical tools and the potential of CT-scan-based finite element analysis for better predictions.
  • - Researchers assessed the reproducibility of a promising model developed in Belgium by comparing it to an independently reproduced model in France, confirming a strong correlation but noting the reproduced model consistently predicts higher failure loads.
  • - The evaluation of the model's application on different datasets showed decreased accuracy in predictions, while the global sensitivity analysis revealed significant factors affecting results, especially the influence of the density calibration coefficient.
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Introduction: The incidence of osteoporotic pelvic fractures is increasing. The broken anterior pelvic ring is preferentially fixed with long intramedullary screws, which require a good understanding of the patient-specific anatomy to prevent joint perforation. The aim of this study was to assess the variability of the superior pubic ramus and the supra acetabular corridors' length and width using statistical shape modelling.

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Purpose Of Review: Recently, photon-counting computed tomography (PCCT) has been introduced in clinical research and diagnostics. This review describes the technological advances and provides an overview of recent applications with a focus on imaging of bone.

Recent Findings: PCCT is a full-body scanner with short scanning times that provides better spatial and spectral resolution than conventional energy-integrating-detector CT (EID-CT), along with an up to 50% reduced radiation dose.

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Subchondral bone remodeling, mediated by osteocytes within the lacuno-canalicular network, plays a crucial role in osteoarthritis (OA) progression. Following cell death, lacunae preserve integrity, offering insights into bone remodeling mechanisms. Limited and controversial data on osteocyte lacuna morphology in OA result from small sample sizes and two-dimensional (2D) techniques that have been used thus far.

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