Publications by authors named "G Halperin"
Objective: To evaluate the safety and efficacy of a chorioamniotic allograft, used as a wound cover for chronic foot ulcers, in patients with diabetes.
Methods: A multicentre, prospective, postmarket study where eligible patients received up to 11 weekly wound cover applications. Computerised planimetry was used to calculate the diabetic foot ulcer (DFU) area each week.
Article Synopsis
- Plague is a severe disease caused by Yersinia pestis, and antibiotic-resistant strains are rising, highlighting the need for new treatments.
- A recombinant Y. pestis strain (Kim53ΔJ+P) showed promising results by triggering a strong and quick immune response in mice against various types of plague.
- The study discovered that this immune response was fast and reliant on interferon-γ, also providing protection against other bacterial infections, suggesting that enhancing innate immune responses could delay disease advancement and improve treatment outcomes.
Frequency Analyses Can Be Improved by a Modified t-test in Sample-based Preclinical Efficacy Studies.
PDA J Pharm Sci Technol
April 2016
Unlabelled: Sample-based preclinical drug efficacy studies compare frequency (proportion) or incidences of successes within respective samples of test and control groups. The word success in principle refers to a protected (e.g.
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- Oxidized phospholipids (Ox-PLs), typically associated with inflammation, may also have anti-inflammatory effects.
- A synthetic Ox-PL analog called VB-201 was tested for its benefits on autoimmune inflammatory disease in the central nervous system (CNS).
- Oral treatment with VB-201 reduced the severity of autoimmune encephalomyelitis (EAE) and inhibited the activation of T-cells responsible for the disease, suggesting a new potential for Ox-PLs in treating CNS inflammatory conditions.
Markers of the early stages of plague, a rapidly progressing deadly disease, are crucial for enabling the onset of an effective treatment. Here, we show that V-antigen protein (LcrV) is accumulated in the serum of Yersinia pestis-infected mice before bacterial colonization of the spleen and dissemination to blood, in a model of bubonic plague. LcrV accumulation is detected earlier than that of F1 capsular antigen, an established marker of disease.
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