The Survey of Barriers for Vaginal Access Surgery Study.

Study Objective: The primary objective of this study was to describe vaginal hysterectomy practice patterns as well as facilitators and inhibitors to performing vaginal hysterectomy among gynecologic surgeons. Secondary objectives were to describe facilitators and inhibitors to the teaching and training of vaginal hysterectomy.

Design: A quantitative analysis of an online survey and qualitative analyses of the one-on-one interviews with gynecologic surgeons were conducted.

Traversing the potential of phytoremediation and phycoremediation as pioneering technologies in microplastic mitigation - A critical review.

With the advent of numerous reports related to health and environmental hazards associated with microplastics (MPs), scientists have been engrossed in developing sustainable technologies for MP mitigation. Conventional methods for the remediation of MPs have several limitations, but with the increasing demand for biological mitigation methods, the latest technologies are prioritized. Among biological-driven methods, phytoremediation and phycoremediation are the two peaking approaches that have gained momentum because of their eco-friendliness, cost-effectiveness, and recyclability options.

In Vivo Tracking and 3D Mapping of Cell Death in Regeneration and Cancer Using Trypan Blue.

Tracking cell death in vivo can enable a better understanding of the biological mechanisms underlying tissue homeostasis and disease. Unfortunately, existing cell death labeling methods lack compatibility with in vivo applications or suffer from low sensitivity, poor tissue penetration, and limited temporal resolution. Here, we fluorescently labeled dead cells in vivo with Trypan Blue (TBlue) to detect single scattered dead cells or to generate whole-mount three-dimensional maps of large areas of necrotic tissue during organ regeneration.

Expected and unexpected effects after systemic inhibition of Hippo transcriptional output in cancer.

Hyperactivation of YAP/TAZ, the Hippo pathway downstream effectors, is common in human cancer. The requirement of YAP/TAZ for cancer cell survival in preclinical models, prompted the development of pharmacological inhibitors that suppress their transcriptional activity. However, systemic YAP/TAZ inhibition may sometimes have unpredictable patient outcomes, with limited or even adverse effects because YAP/TAZ action is not simply tumor promoting but also tumor suppressive in some cell types.

Efficacy of exopolysaccharide in dye-laden wastewater treatment: A comprehensive review.

The discharge of dye-laden wastewater into the water streams causes severe water and soil pollution, which poses a global threat to aquatic ecosystems and humans. A diverse array of microorganisms such as bacteria, fungi, and algae produce exopolysaccharides (EPS) of different compositions and exhibit great bioflocculation potency to sustainably eradicate dyes from water bodies. Nanomodified chemical composites of EPS enable their recyclability during dye-laden wastewater treatment.