The coordination chemistry and anticancer activity of organo-ruthenium(II), -iridium(III) and -rhodium(III) complexes with sulfonyl-substituted thiourea ligands.

Some half-sandwich compounds with a variety of ligands and metal centres have shown promising anticancer activity. Herein we report a series of reactions between the sulfonylthiourea ligands -TolSONHC(S)NHPh, EtSONHC(S)NHPh and CHSONHC(S)NHPh and [(η--cymene)RuCl], [(η-arene)RuCl(PR)] (arene = benzene or -cymene), [Cp*MCl(PR)] or [Cp*RhCl] (M = Ir(III), Rh(III)), Cp* = η-pentamethylcyclopentadienyl, PR = triphenylphosphine (PPh), tris(2-cyanoethyl)phosphine (tcep) and 1,3,5-triaza-7-phosphaadamantane (pta) and their corresponding piano stool complexes. Single crystal X-ray diffraction structure determinations indicated that the resulting linkage isomer of the complex, , (coordination S,N placing the sulfonyl group near the coordination sphere) or (coordination S,N, placing the sulfonyl group away from the coordination sphere), is directly related to the steric bulk around the metal centre.

Intracerebral delivery of antiseizure medications by microinvasive neural implants.

Focal epilepsy is a difficult disease to treat as two-thirds of patients will not respond to oral anti-seizure medications (ASMs) or have severe off-target effects that lead to drug discontinuation. Current non-pharmaceutical treatment methods (resection or ablation) are underutilized due to the associated morbidities, invasive nature and inaccessibility of seizure foci. Less invasive non-ablative modalities may potentially offer an alternative.

Stabilization of 3-Helices in Macrocycles Using Dominant Rotor Methodology.

Stabilization of biologically relevant structural motifs has been a long-standing challenge. Here we show that atropisomeric dominant rotors can stabilize rare 3-helices in macrocycles. The target molecules were prepared using solid-phase peptide synthesis and subjected to extensive structural analysis.