Publications by authors named "G H KleinJan"
Article Synopsis
- This study aimed to compare the effectiveness of a hybrid tracer (ICG-Tc-nanocolloid) versus sequential tracers (Tc-nanocolloid and free-ICG) in detecting cancerous lymph nodes during prostate cancer surgery.
- It involved prostate cancer patients with a significant risk of lymphatic involvement, who were randomly assigned to receive either the hybrid or sequential tracer before surgery.
- Results showed similar total numbers of removed lymph nodes between both groups, but the hybrid group retrieved fewer fluorescence nodes, and there was no significant difference in the number of tumor-positive lymph nodes detected.
Article Synopsis
- In muscle-invasive bladder cancer (MIBC), lymph node involvement is a key factor in predicting disease recurrence and survival, prompting the study of sentinel node (SN) biopsy using a hybrid tracer for better detection.
- The research included 20 MIBC patients, using ICG-99m Tc-nanocolloid injections to visualize SNs before surgery, with 19 patients showing results post-operation.
- Results indicated that SNs were identified in over half of the patients, and while some patients had tumor-positive nodes, two with no preoperative visualization showed SNs during surgery, suggesting that this method is a viable option for improved cancer staging.
Purpose: Surgical fluorescence guidance has gained popularity in various settings, e.g., minimally invasive robot-assisted laparoscopic surgery.
View Article and Find Full Text PDFIntroduction: Previous studies indicated that location and amount of detected sentinel lymph nodes (SLNs) in prostate cancer (PCa) are influenced where SLN-tracer is deposited within the prostate. To validate whether intratumoral (IT) tracer injection helps to increase identification of tumor-positive lymph nodes (LNs) better than intraprostatic (IP) tracer injection, a prospective randomized phase II trial was performed.
Methods: PCa patients with a > 5% risk of lymphatic involvement were randomized between ultrasound-guided transrectal injection of indocyanine green-[Tc]Tc-nanocolloid in 2 depots of 1 mL in the tumor (n = 55, IT-group) or in 4 depots of 0.
Sentinel lymph node (SN) biopsy (SNB) has proven to be a valuable tool for staging melanoma patients. Since its introduction in the early 1990s, this procedure has undergone several technologic refinements, including the introduction of SPECT/CT, as well as radioguidance and fluorescence guidance. The purpose of the current study was to evaluate the effect of this technologic evolution on SNB in the head and neck region.
View Article and Find Full Text PDF