Previous research shows that a single session of anodal transcranial direct current stimulation (tDCS) to the left dorsolateral prefrontal cortex (dlPFC) can improve the accuracy of episodic memory retrieval, but stimulation effects are not always found and may be moderated by time of day. Here, we report the results from a rigorous clinical trial (NCT03723850) designed to replicate these tDCS findings in younger adults and extend them to cognitively normal older adults. We conducted the largest double-blind, between-subjects tDCS study on memory retrieval in younger and older adults to date.
View Article and Find Full Text PDFAndrogen independent phase in prostate cancer (PCa) commonly limits the therapeutic efficacy. through its main active compound, α-thujone, appears to be an option, considering its anti-proliferative, anti-metastatic and pro-apoptotic effects on hepatocellular carcinoma. However, studies on PCa are limited.
View Article and Find Full Text PDFBackground: Diagnosing red legs on first presentation is challenging. There exists a lack of robustly developed and validated diagnostic red leg tools in clinical practice. Physicians fear missing cases of infectious red legs and treat many patients unnecessarily with antibiotics.
View Article and Find Full Text PDFBackground: The American College of Surgeons National Surgical Quality Improvement Project (ACS-NSQIP) uses Current Procedural Terminology (CPT) codes for risk-adjusted calculations. This study evaluates the inter-rater reliability of coding colorectal resections across Canada by ACS-NSQIP surgical clinical nurse reviewers (SCNR) and its impact on risk predictions.
Methods: SCNRs in Canada were asked to code simulated operative reports.