Crystal structures of four thio-glycosides involving carbamimido-thio-ate groups.

The compounds 2',3',4',6'-tetra--acetyl-β-d-gluco-pyranosyl '-cyano--phenyl-carbamimido-thio-ate (CHNOS, ), 2',3',4',6'-tetra--acetyl-β-d-galacto-pyranosyl '-cyano-phenyl-carbamimido-thio-ate, (CHNOS, ), 2',3',4',6'-tetra--acetyl-β-d-galacto-pyranosyl '-cyano--methyl-carbamimido-thio-ate (CHNOS, ), and 2',3',4',6'-tetra--acetyl-β-d-galacto-pyranosyl '-cyano---tolyl-carbamimido-thio-ate (CHNOS, ) all crystallize in 222 with = 4. For all four structures, the configuration across the central (formal) C=N(CN) double bond of the carbamimido-thio-ate group is . The torsion angles C5-O1-C1-S (standard sugar numbering) are all close to 180°, confirming the β position of the substituent.

Novel synthesis of the first new class of triazine sulfonamide thioglycosides and the evaluation of their anti-tumor and anti-viral activities against human coronavirus.

Novel class of triazine sulfonamide thioglycosides was designed and synthesized. Those novel structures comprising three essential and pharmacological significant moieties such as the triazine, sulfonamide, and thioglycosidic scaffolds. The triazine sulfonamides were furnished a direct approach starting from potassium cyanocarbonimidodithioate, then the corresponding triazine sulfonamide thioglycosides were generated using the peracylated -d-- and galacto-pyranosyl bromides.

Design and synthesis of novel 1,3,4-thiadiazole thioglycosides as promising antimicrobial potent structures.

Thiosemicarbazide was used as a key starting material for the building of a diversity of novel heterocyclic moieties. The heterocyclization reaction of thiosemicarbazide derivatives with carbon disulfide in basic conditions afforded novel heterocyclic 1,3,4-thiadiazolethiolate derivatives. 1,3,4-thiadiazole-2-thiol was successfully reacted with protected α-D-gluco- and galacto-pyranosyl bromides in dimethylformamide at room temperature to give the matching 1,3,4-thiadiazole -glycosides in good yields.

Crystal structure of ()--(4-bromo-phen-yl)-2-cyano-3-[3-(2-methyl-prop-yl)-1-phenyl-1-pyrazol-4-yl]prop-2-enamide.

The structure of the title compound, CHBrNO, contains two independent mol-ecules connected by hydrogen bonds of the type N-H⋯N≡C to form a dimer. The configuration at the exocyclic C=C double bond is . The mol-ecules are roughly planar except for the isopropyl groups.

Synthesis and crystal structure of -phenyl-2-(phenyl-sulfan-yl)acetamide.

-Phenyl-2-(phenyl-sulfan-yl)acetamide, CHNOS, was synthesized and structurally characterized. In the crystal, N-H⋯O hydrogen bonding leads to the formation of chains of mol-ecules along the [100] direction. The chains are linked by C-H⋯π inter-actions, forming a three-dimensional network.