Publications by authors named "G H Eckstein"

Article Synopsis
  • Huntington's disease (HD) is linked to psychiatric symptoms, but the effects of variations in the huntingtin gene (HTT) CAG repeat sizes on psychiatric disorders like major depressive disorder (MDD) and anxiety disorders (ANX) are not well-studied.
  • In this study, researchers compared CAG repeat sizes among patients with MDD and ANX to healthy controls, finding that certain repeat ranges did not show an overrepresentation among patients and that age influenced the associations between repeat sizes and psychiatric risks.
  • The findings suggest that variations in CAG repeat sizes in the non-HD range can modulate the risk for psychiatric disorders and affect basal ganglia structure, highlighting the potential impact of the normal huntingtin protein
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The number of women of childbearing age who have been diagnosed in childhood with ion channelopathy and effectively treated using beta blockers, cardiac sympathectomy, and life-saving cardiac pacemakers/defibrillators is increasing. Since many of these diseases are inherited as autosomal dominant, offspring have about a 50% risk of having the disease, though many will be only mildly impacted during fetal life. However, highly complex delivery room preparation is increasingly needed in pregnancies with inherited arrhythmia syndromes (IASs).

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One of the most successful achievements of fetal intervention is the pharmacologic management of fetal arrhythmias. This management usually takes place during the second or third trimester. While most arrhythmias in the fetus are benign, both tachy- and bradyarrhythmias can lead to fetal hydrops or cardiac dysfunction and require treatment under certain conditions.

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