Publications by authors named "G H Chun"
Neuromodulatory signaling is poised to serve as a neural mechanism for gain control, acting as a crucial tuning factor to influence neuronal activity by dynamically shaping excitatory and inhibitory fast neurotransmission. The endocannabinoid (eCB) signaling system, the most widely expressed neuromodulatory system in the mammalian brain, is known to filter excitatory and inhibitory inputs through retrograde, pre-synaptic action. However, whether eCBs exert retrograde gain control to ultimately facilitate reward-seeking behaviors in freely moving mammals is not established.
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- - This clinical trial compared the safety and effectiveness of an inhaled COVID-19 vaccine (Ad5-nCoV-IH) against an intramuscular vaccine (BNT-IM) in 540 vaccinated adults in Malaysia from September 2022 to May 2023.
- - While Ad5-nCoV-IH exhibited lower immunogenicity (with a GMC ratio of 0.22) compared to BNT-IM, it resulted in fewer adverse drug reactions (39.26% vs. 64.68%) and no serious side effects were documented.
- - Both vaccines demonstrated similar efficacy against COVID-19 variants, but the study concluded that Ad5-nCoV-IH did not meet the non
Gender differences in hepatitis A seropositivity rates according to the Republic of Korea's vaccination policy.
Osong Public Health Res Perspect
April 2024
Article Synopsis
- - The study analyzed anti-hepatitis A virus (HAV) antibody levels from over 1.3 million tests conducted between 2012 and 2022, focusing on age and gender differences in seropositivity rates.
- - Results showed a U-shaped pattern, with lower seropositivity rates for those aged 20 to 39, but higher rates for younger and older individuals, while the rates gradually declined for those aged 35 and older.
- - A significant gender gap was observed, especially in men aged 20 to 29, likely influenced by military enlistment, highlighting the need for targeted vaccination policies for adults to reduce severe infection risks.
Background: Medication burden and complexity have been longstanding problems in chronically ill patients. However, more data are needed on the extent and impact of medication burden and complexity in the transfusion-dependent thalassaemia population.
Aim: The aim of this study was to determine the characteristics of medication complexity and polypharmacy and determine their relationship with drug-related problems (DRP) and control of iron overload in transfusion-dependent thalassaemia patients.
Article Synopsis
- The study reviews the impact of poor compliance with iron-chelation therapy (ICT) on health outcomes and quality of life in thalassemia patients, emphasizing its significance due to risks associated with iron overload.
- Out of 4917 studies examined, 20 were included, showing ICT compliance rates ranging from approximately 21% to 100%, depending on the medication used.
- Higher compliance is associated with lower serum ferritin levels and reduced risks of liver and cardiac diseases, as well as improved health-related quality of life, but caution is advised due to limited evidence.