Publications by authors named "G H Chee"
Article Synopsis
- The study assessed the safety and tolerability of bulevirtide (BLV), a new treatment for chronic hepatitis delta (CHD), by analyzing data from three clinical trials involving 269 patients.
- The findings indicated that certain adverse events, such as increased bile acid levels and injection-site reactions, were more common with BLV compared to a control group, but serious side effects were minimal and did not lead to treatment discontinuation.
- Overall, BLV was deemed safe and well tolerated over 48 weeks of therapy in patients with CHD, showing promise as an effective treatment option.
Article Synopsis
- A phase 2b trial tested the effectiveness of bulevirtide combined with peginterferon alfa-2a compared to peginterferon alone and bulevirtide alone in treating chronic hepatitis D over 48 weeks, with follow-up for an additional 48 weeks.* -
- Results showed that 46% of patients receiving the 10 mg bulevirtide and peginterferon had undetectable levels of the hepatitis D virus 24 weeks after treatment, compared to only 17% in the peginterferon alone group.* -
- The combination therapy indicated a statistically significant improvement in viral response, suggesting that bulevirtide and peginterferon could be a beneficial treatment strategy
Background & Aims: Bulevirtide (BLV), a first-in-class entry inhibitor, is approved in Europe for the treatment of chronic hepatitis delta (CHD). BLV monotherapy was superior to delayed treatment at week (W) 48, the primary efficacy endpoint, in the MYR301 study (NCT03852719). Here, we assessed if continued BLV therapy until W96 would improve virologic and biochemical response rates, particularly among patients who did not achieve virologic response at W24.
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- The study investigated how repeated cycles of wearing and decontaminating N95 masks affect their fit and integrity during the early COVID-19 pandemic.
- Researchers tested different decontamination methods (moist heat, steam, UV-C, and hydrogen peroxide plasma) and found that moist heat maintained mask integrity across all five cycles, while 60.6% to 77.5% of masks overall passed fit tests.
- The findings suggest that moist heat is an effective decontamination method for N95 masks, potentially reducing medical waste and promoting sustainability in future mask usage.
Background: The importance of immunization for child survival underscores the need to eliminate immunization inequalities. Few existing studies of inequalities use approaches that view the challenges and potential solutions from the perspective of caregivers. This study aimed to identify barriers and context-appropriate solutions by engaging deeply with caregivers, community members, health workers, and other health system actors through participatory action research, intersectionality, and human-centered design lenses.
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