Publications by authors named "G H BECKER"
Zoonotic infections (swine-human) caused by influenza A viruses (IAVs) have been reported and linked to close contact between these species. Here, we describe eight human IAV variant infections (6 mild and 2 severe cases, including 1 death) detected in Paraná, Brazil, during 2020-2023. Genomes recovered were closely related to Brazilian swIAVs of three major lineages (1 A.
View Article and Find Full Text PDFHIV Knowledge and Sexual Behaviors in Perinatally Infected Ugandan Youth: A Cross-Sectional Survey.
J Int Assoc Provid AIDS Care
December 2024
Our objective was to assess human immunodeficiency virus (HIV) knowledge and sexual behaviors in 294 perinatally HIV-infected youth aged 18 to 25 years from a psychosocial support group in Kampala using a self-administered survey. Seventy-nine percent reported an undetectable viral load, 9.5% detectable, and 12% did not know.
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- * A study using genotypes from 81 flocks found that nearly all genetic variation (99.9%) comes from a single ancestral population, suggesting a current population size of around 150, but the breed should actually target a reference population of 15,000 for better genomic prediction accuracy.
- * The average inbreeding level was about 16.6%, with specific genomic regions linked to production traits showing high levels of shared genetic material; addressing these could help improve selection outcomes,
Propionic and methylmalonic acidemias (PAcidemia and MMAcidemia, respectively) are genetic disorders characterized by acute metabolic decompensation and neurological complications. L-carnitine (LC) is effective in reducing toxic metabolites that are related to the pathophysiology of these diseases. Therefore we investigated biomarkers of inflammation (cytokines and C-reactive protein (CRP)), neurodegeneration (BDNF, NCAM-1 and cathepsin-D) and biomolecules oxidation (sulfhydryl content and thiobarbituric acid-reactive species (TBARS)), as well as carnitine concentrations in untreated patients with PAcidemia and MMAcidemia, in patients under treatment with LC and a protein-restricted diet for until 2 years and in patients under the same treatment for more than 2 years.
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- Propionic and methylmalonic acidemias are serious genetic disorders in newborns that cause dangerous metabolic crises, necessitating swift treatment for survival.
- A study found that a low-protein diet paired with L-carnitine supplements can reduce the harmful effects and risks associated with these conditions by lowering toxic metabolite levels.
- Long-term treatment with this diet and supplements showed promising results in reducing markers of oxidative damage in patients, suggesting potential protective effects against further complications, although more research is needed to link oxidative stress directly to patient health outcomes.