Molecular mechanisms underlying allosteric behavior of Escherichia coli DgoR, a GntR/FadR family transcriptional regulator.

GntR/FadR family featuring an N-terminal winged helix-turn-helix DNA-binding domain and a C-terminal α-helical effector-binding and oligomerization domain constitutes one of the largest families of transcriptional regulators. Several GntR/FadR regulators govern the metabolism of sugar acids, carbon sources implicated in bacterial-host interactions. Although effectors are known for a few sugar acid regulators, the unavailability of relevant structures has left their allosteric mechanism unexplored.

From Frustration to Order: Role of Fluid-Fluid Interfaces in Precision Assembly of Nanoparticles.

Fluid-fluid interfaces are an attractive platform for self-assembling nanoparticles into low-dimensional materials. In this Perspective, we review recent developments in the use of interfaces to direct the assembly of spherical and anisotropic nanoparticles into diverse and sophisticated architectures. We illustrate how nanoparticle clusters, strings, networks, superlattices, chiral lattices, and quasicrystals can be self-assembled by harnessing the frustration between interfacial and interparticle forces.

Thiazolidine-4-one Analogues: Synthesis, In-Silico Molecular Modeling, and In-vivo Estimation for Anticonvulsant Potential.

Background: Epilepsy is a critically deep-rooted CNS disorder affecting above 50 million people all over the world. Thus, a safe and effective treatment that proves its worth in this ailment is urgently needed. Thiazolidine-4-ones possess the molecules to be used as anticonvulsants.

Enhanced bioavailability and efficacy in antimalarial treatment through QbD approach enteric encased inclusion delivery.

In this study, we aimed to prepare enteric encapsulated spheroids containing inclusion complex using quality by design approach. A Box-Behnken design was employed to determine effects of variables on selected responses. Risk assessment was conducted using Ishikawa fishbone diagram.