Evaluation of Cannabis Per Se Laws: A Semi-Mechanistic Pharmacometrics Model for Quantitative Characterization of THC and Metabolites in Oral Users.

Recreational cannabis use has increased notably in the United States in the past decade, with a recent surge in oral consumption. This trend has raised concerns about driving under the influence. Current cannabis-impaired driving laws lack standardization, with some states implementing blood Δ9-tetrahydrocannabinol (THC) per se limits (1, 2, and 5 ng/mL).

Analysis of mechanical properties and energy evolution mechanism of frozen calcareous clay under multi-factor interaction.

Research investigating the complex mechanical properties and energy evolution mechanisms of frozen calcareous clay under the influence of multiple factors is crucial for optimizing the artificial ground freezing method in shaft sinking, thereby enhancing construction quality and safety. In this study, a four-factor, four-level orthogonal test was devised, taking into account temperature, confining pressure, dry density, and water content. The complex nonlinear curvilinear relationship between deviatoric stress, volume strain, and axial strain of frozen calcareous clay under different interaction levels was analyzed.

Hierarchical Optimization Segmentation and Parameter Extraction of Street Trees Based on Topology Checking and Boundary Analysis from LiDAR Point Clouds.

Roadside tree segmentation and parameter extraction play an essential role in completing the virtual simulation of road scenes. Point cloud data of roadside trees collected by LiDAR provide important data support for achieving assisted autonomous driving. Due to the interference from trees and other ground objects in street scenes caused by mobile laser scanning, there may be a small number of missing points in the roadside tree point cloud, which makes it familiar for under-segmentation and over-segmentation phenomena to occur in the roadside tree segmentation process.

Targeting Enterobacter cloacae attenuates osteolysis by reducing ammonium in multiple myeloma.

Multiple myeloma (MM)-induced bone disease affects not only patients' quality of life but also their overall survival. Our previous work demonstrated that the gut microbiome plays a crucial role in MM progression and drug resistance. However, the role of altered gut microbiota in MM bone disease remains unclear.

[Progress in risk stratification and treatment of high-risk smoldering multiple myeloma].

Smoldering multiple myeloma (SMM) patients are a heterogeneous group with variable prognosis. A subset of SMM patients have a higher risk of progressing to multiple myeloma (MM) within 2 years. The definition of high-risk patients is not consistent among different risk models, and the combination of various biomarkers and new technologies improves the predictive performance of risk models.