Publications by authors named "G H Adan"
The knee jerk reflex, emblematic of neurology and central to clinical practice, marks its 150th anniversary in 2025. First introduced to the neurological literature in 1875 through independent reports by Wilhelm Erb and Carl Westphal, this reflex has since evolved from a clinical curiosity to a diagnostic staple, although its initial interpretation was debated. Erb viewed it as a spinal reflex, whereas Westphal questioned its reflex nature, considering mechanical muscle excitation.
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- There is a lack of standard outcomes being measured in studies for adult epilepsy treatments, making it hard to assess their effectiveness.
- As part of a project to create a Core Outcome Set, researchers analyzed 104 trials and found 374 unique outcome terms that fit into 45 different concepts, covering multiple areas like seizures and emotional functioning.
- Most studies only measured 10 out of the 45 concepts frequently, reflecting a significant inconsistency in how outcomes are reported, which emphasizes the need for standardized outcomes in future epilepsy clinical trials.
Article Synopsis
- * This study involved a comparison between individuals with newly diagnosed focal epilepsy (NDfE) and healthy controls, using MRI and neuropsychological data to evaluate subcortical shape alterations and their impact on brain connectivity and cognitive function.
- * Findings indicated significant inward deformation (localized atrophy) in the thalamus and pallidum of NDfE patients, and a correlation between reduced white matter integrity (measured by fractional anisotropy) and this shape deformation, suggesting links to neuropsychological outcomes.
Imagery as a Participatory Tool of Resilience for Marginalized Persons.
Am J Public Health
February 2024
Neurocysticercosis (NCC)-a parasitic CNS infection endemic to developing nations-has been called the leading global cause of acquired epilepsy yet remains understudied. It is currently unknown why a large proportion of patients develop recurrent seizures, often following the presentation of acute seizures. Furthermore, the presentation of NCC is heterogenous and the features that predispose to the development of an epileptogenic state remain uncertain.
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