Publications by authors named "G Gulati"
The integrative physiology of the left ventricle and systemic circulation is fundamental to our understanding of advanced heart failure and cardiogenic shock. In simplest terms, any increase in aortic stiffness increases the vascular afterload presented to the failing left ventricle. The net effect is increased myocardial oxygen demand and reduced coronary perfusion pressure, thereby further deteriorating contractile function.
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- - This study investigates which models of vascular afterload best predict right-sided heart dysfunction in patients with newly diagnosed pulmonary hypertension (PH), focusing on factors like pulmonary vascular resistance (PVR) and pulmonary arterial compliance (PAC).
- - Researchers analyzed data from 86 patients using right-sided heart catheterization and cardiac magnetic resonance imaging, revealing that PVR was the most accurate predictor for several measures of heart dysfunction, except when PVR was low, where PAC showed better predictive power.
- - A combined model using PVR, PAC, and characteristic impedance provided the best prediction for right atrial volume changes, and a specific PAC threshold (<2.3 mL/mm Hg) was identified as a strong predictor for right-sided heart dysfunction in
Messenger RNA (mRNA) vaccines against COVID-19 have demonstrated high efficacy and rapid deployment capability to target emerging infectious diseases. However, the need for ultra-low temperature storage made the distribution of LNP/mRNA vaccines to regions with limited resources impractical. This study explores the use of lyophilization to enhance the stability of self-replicating mRNA (repRNA) vaccines, allowing for their storage at non-freezing temperatures such as 2-8 °C or room temperature (25 °C).
View Article and Find Full Text PDFBone marrow endothelial cells (BM-ECs) are the essential components of the BM niche and support the function of hematopoietic stem cells (HSCs). However, conditioning for HSC transplantation causes damage to the recipients' BM-ECs and may lead to transplantation-related morbidity. Here, we investigated the cellular and clonal mechanisms of BM-EC regeneration after irradiative conditioning.
View Article and Find Full Text PDFRespiratory syncytial virus (RSV) is a major cause of bronchiolitis in infants and young children. Bronchiolitis, an acute inflammation of the lower respiratory tract, can lead to pneumonia, respiratory failure, and death. We aimed to compare the incidence and severity of RSV infection in children aged 0-60 months before and during the coronavirus disease 2019 (COVID-19) pandemic.
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