[Guide to the treatment of paediatric strokes. Iberoamerican Academy of Pediatric Neurology].

A paediatric stroke is a rare entity that can occur at any age. It may be arterial or venous, ischemic or haemorrhagic, and may occur in the neonatal or paediatric stage of life, as well as in adolescence. Prompt diagnosis means that adequate treatment can be administered and prevents recurrence, minimising the percentage of sequelae.

A magnetohydrodynamic mechanism for the formation of solar polar vortices.

Polar vortices are ubiquitous features of planetary atmospheric flows, from the Earth-like rocky planets to Jupiter- and Saturn-like gas giant planets. Very little is known about their existence or dynamics on the Sun. What should be expected near the Sun's pole for the upcoming solar multi-viewpoint and polar missions? Here, we report the magnetohydrodynamic (MHD) nonlinear simulations for the formation and evolution of solar polar vortices using a near-surface MHD shallow-water model.

Pharmacologically enabling the degradation of NaV1.8 channels to reduce neuropathic pain.

In phase II clinical trials, NaV1.8 channels were identified as viable targets to treat acute pain. Results were modest, however, and NaV1.

Modeling Patient-specific Apnea-bradycardia Patterns in Preterm Newborn.

Objective: Preterm infants are particularly exposed to severe cardio-respiratory events, associating apnea with bradycardia and oxygen desaturation. A patient-specific and event-specific model-based approach is proposed in this work to analyze the acute heart rate response to apnea-bradycardia events in preterm newborn.

Methods: A novel model integrating the main cardio-respiratory interactions which are specific to the neonatal period is proposed.

The GTPase RAB6 is required for stem cell maintenance and cell migration in the gut epithelium.

Intestinal epithelial cells, which are instrumental in nutrient absorption, fluid regulation, and pathogen defense, undergo continuous proliferation and differentiation within the intestinal crypts, migrating towards the luminal surface where they are eventually shed. RAB GTPases are key regulators of intracellular vesicular trafficking and are involved in various cellular processes, including cell migration and polarity. Here, we investigated the role of RAB6 in the development and maintenance of the gut epithelium.