Publications by authors named "G Grzych"
Article Synopsis
- The study investigates the effectiveness of a rapid immunoassay technique (Snibe) versus mass spectrometry (LC-MS/MS) in measuring plasma homocysteine levels, particularly in patients with nitrous oxide abuse.
- Significant elevations in plasma homocysteine were found in nitrous oxide abusers, with the immunoassay delivering faster results, although it generally underestimated high levels compared to LC-MS/MS.
- The findings highlight the need for the immunoassay as a quick initial screening tool, while still recommending confirmation with LC-MS/MS for accurate diagnosis of conditions associated with oxidative stress.
Laboratory medicine plays a crucial role in patient care, contributing to approximately 70 % of clinical decisions. In collaboration with clinicians, laboratory medicine specialists perform analyses that are useful for diagnosis, screening and prevention. Laboratories are known for their efficiency, which is reached through a rigorous quality system.
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- The study investigates the rising neurological complications from nitrous oxide (NO) abuse, particularly focusing on two main types of nerve damage: axonal and demyelinating neuropathy.
- Researchers examined 35 patients with sensorimotor symptoms linked to recreational NO use, gathering a variety of data to categorize their conditions and assess metabolic factors.
- Findings reveal that many patients had length-dependent axonal neuropathy, while a significant portion presented demyelinating features, with metabolic markers like homocysteine and methylmalonic acid varying between the two groups, suggesting these may help in understanding the condition better.
The recreational use of nitrous oxide (N2O) is an emerging public health issue. Chronic N2O abuse may result in various clinical symptoms, encompassing neurological, psychiatric and cardiovascular outcomes. Despite the difficulties for the laboratory investigation of N2O intoxication, there is currently no guidelines in France to help both clinicians and biologists use appropriate biomarkers for the diagnosis and monitoring of patients with clinical symptoms potentially related to N2O intoxication.
View Article and Find Full Text PDFRecreational use of nitrous oxide (NO) has become a major health issue worldwide, with a high number of clinical events, especially in neurology and cardiology. It is essential to be able to detect and monitor NO abuse to provide effective care and follow-up to these patients. Current recommendations for detecting NO in cases of recreational misuse and consumption markers are lacking.
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