Publications by authors named "G Grossman"
Salmonid fishes are a widespread and economically important group of fishes that are strongly affected by anthropogenic environmental degradation. Consequently, studies on their behavior and ecology are essential for their conservation. Wild Arctic grayling (Thymallus arcticus) were observed in an unimpacted Alaskan river using underwater video observations for two consecutive summers (2015 and 2016).
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- The study investigates changes in the optic nerve head and retina of brain-dead organ donors after varying durations of elevated intraocular pressure (IOP).
- Researchers examined optic and retinal tissues from three donors, revealing significant differences in protein and mRNA expression related to astrocytic markers and inflammation depending on the duration of IOP elevation.
- Findings suggest that longer periods of elevated IOP lead to more pronounced changes in both the optic nerve and retina, and highlight the potential of using this model for further understanding the mechanotranscriptomic responses in eye conditions.
Background: ISCHEMIA (International Study of Comparative Health Effectiveness With Medical and Invasive Approaches) did not find an overall reduction in cardiovascular events with an initial invasive versus conservative management strategy in chronic coronary disease; however, there were conservative strategy participants who underwent invasive coronary angiography early postrandomization (within 6 months). Identifying factors associated with angiography in conservative strategy participants will inform clinical decision-making in patients with chronic coronary disease.
Methods: Factors independently associated with angiography performed within 6 months of randomization were identified using Fine and Gray proportional subdistribution hazard models, including demographics, region of randomization, medical history, risk factor control, symptoms, ischemia severity, coronary anatomy based on protocol-mandated coronary computed tomography angiography, and medication use.