Structural Manipulation of the Conjugated Phenyl Moiety in 3-Phenylbenzofulvene Monomers: Effects on Spontaneous Polymerization.

Spontaneous polymerization is an intriguing phenomenon in which pure monomers begin their polymerization without initiators or catalysts. Previously, 3-phenylbenzofulvene monomers were found to polymerize spontaneously after solvent removal. Here, eight new 3-substituted benzofulvene monomers were synthesized in order to investigate the effects of differently substituted aromatic rings in position 3 of the benzofulvene scaffold on spontaneous polymerization.

Densely PEGylated Polybenzofulvene Brushes for Potential Applications in Drug Encapsulation.

The technique of grafting side chains onto a linear polymeric backbone is commonly used to confer to the new polymeric material with desired properties, such as tunable solubility, ionic charge, biocompatibility, or specific interactions with biological systems. In this paper, two new polybenzofulvene backbones were assembled by spontaneous polymerization of the appropriate benzofulvene monomers (4,6-PO- and 4',6-PO-) bearing two clickable propargyloxy groups in different positions of the 3-phenylindene scaffold. Poly-4,6-PO- and poly-4',6-PO- were grafted with monomethyl oligo(ethylene glycol) (MOEG) to prepare two new polybenzofulvene brushes (i.

Development of subnanomolar-affinity serotonin 5-HT receptor ligands based on quinoline structures.

Two small series of quinoline derivatives were designed starting from previously published quinoline derivatives and in order to obtain information about their interaction with the 5-HTR binding site. Initially, the structure of and was modified by replacing their basic moiety with that of partial agonist (ML10302) or with that of reference ligand (RS-67-333). Then, the aromatic moieties of 4-quinolinecarboxylates , , and or 4-quinolinecarboxamides , , and were modified into those of 2-quinolinecarboxamides .

Hyaluronan-based graft copolymers bearing aggregation-induced emission fluorogens.

In order to develop a technology platform based on two natural compounds from biorenewable resources, a short series of hyaluronan (HA) copolymers grafted with propargylated ferulic acid (HA-FA-Pg) were designed and synthesized to show different grafting degree values and their optical properties were characterized in comparison with reference compounds containing the same ferulate fluorophore. Interestingly, these studies revealed that the ferulate fluorophore was quite sensitive to the restriction of intramolecular motion and its introduction into the rigid HA backbone, as in HA-FA-Pg graft copolymers, led to higher photoluminescence quantum yield values than those obtained with the isolated fluorophore. Thus, the propargyl groups of HA-FA-Pg derivatives were exploited in the coupling with oleic acid through a biocompatible nona(ethylene glycol) spacer as an example of the possible applications of this technology platform.

Nanosphere lithography for optical fiber tip nanoprobes.

This paper reports a simple and economical method for the fabrication of nanopatterned optical fiber nanotips. The proposed patterning approach relies on the use of the nanosphere lithography of the optical fiber end facet. Polystyrene (PS) nanospheres are initially self-assembled in a hexagonal array on the surface of water.