Publications by authors named "G Grimod"
Article Synopsis
- Glioblastoma (GBM) is a highly aggressive brain cancer with few treatment options, and the study focuses on exploring extracellular vesicles (EVs) from GBM cells as potential diagnostic biomarkers.
- * The research utilized tumor explants from GBM patients to preserve tumor characteristics and successfully isolated EVs, analyzing their surface markers through advanced techniques.
- * Results showed unique surface biomarker expression patterns in GBM-derived EVs that could differentiate them from healthy controls, indicating their potential role in noninvasive diagnosis and understanding of GBM progression.
Background: Treatment-related changes still represent a diagnostic challenge in the management of patients with suspect of recurrent glioblastoma. The specificity of conventional MRI in detecting recurrence remains limited. Brain PET imaging provides information on tumor metabolism and can contribute to improving the diagnostic accuracy of cerebral neoplasms.
View Article and Find Full Text PDFCirculating tumor cells (CTCs) are one of the most important causes of tumor recurrence and distant metastases. Glioblastoma (GBM) has been considered restricted to the brain for many years. Nevertheless, in the past years, several pieces of evidence indicate that hematogenous dissemination is a reality, and this is also in the caseof GBM.
View Article and Find Full Text PDFBackground: The aim of this study was to achieve a consensus on the minimum set of outcome measures and predictors to be used in the neurosurgical practice and on the timing of outcome assessment.
Methods: A consensus building approach was employed. All neurosurgical departments in Lombardy (Italy) were invited to participate by the Carlo Besta Neurologic Institute IRCCS Foundation.
Purpose Of Review: The aim of this study is to discuss surgical management of meningiomas and schwannomas of skull base.
Recent Findings: Meningiomas and schwannomas are typically benign neoplasm with a good prognosis after surgery. Patients should be treated individually related to several features: size and localization of tumor and its proximity with deep critical neurovascular structures, neurological status, age and comorbidity.