Publications by authors named "G Grimaldi Junior"
The global increase in cancer cases and mortality has been associated with inflammatory processes, in which chemokines play crucial roles. These molecules, a subfamily of cytokines, are essential for the migration, adhesion, interaction, and positioning of immune cells throughout the body. Chemokines primarily originate in response to pathogenic stimuli and inflammatory cytokines.
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- This study systematically reviews methods for extracting and analyzing organic contaminants in crab urine, which are essential due to crabs' role as bioindicators of aquatic contamination.
- Although harmful substances like PCBs and pesticides are known to affect ecosystems, most studies have focused mainly on PAHs, leaving a significant research gap.
- The perception that collecting crab urine is difficult, along with insufficient methodologies in existing literature, highlights the need for more extensive research to improve ecological understanding and environmental monitoring efforts.
Article Synopsis
- - The study presents a new method for separating extracellular vesicles (EVs) from plasma, focusing on their surface charges to improve the purity of EVs and reduce contamination by free plasma proteins.
- - This charge-based fractionation technique was optimized through various analyses, including proteomics and electron microscopy, ensuring the effective isolation of EVs from healthy donors.
- - The method was tested on clinical prostate cancer samples, showing promise for enhancing EV-based diagnostics and research, while also being user-friendly and accessible without specialized equipment.
6-Nitrodopamine (6-ND) is the predominant catecholamine released from isolated vascular tissues in both mammals and reptiles, with its release being significantly reduced by the NO synthesis inhibitor, N-nitro-L-arginine methyl ester (L-NAME). The vasorelaxation induced by 6-ND is unaffected by either L-NAME or the soluble guanylate cyclase (sGC) inhibitor, ODQ, indicating an alternative mechanism of action. The vasorelaxant effect appears to be mediated through selective antagonism of dopamine D receptors rather than traditional nitric oxide (NO)-mediated pathways.
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