Laser-induced fluorescence diagnosis and photodynamic therapy of human renal cell carcinoma.

Photodynamic therapy (PDT) has recently attracted much attention, especially among urologists, because it appears to be a selective form of cancer treatment which causes minimal damage to normal surrounding tissues. In this study we made use of a new class of photosensitizers for the laser-induced fluorescence diagnosis (LIFD) and photodynamic therapy of human renal cell carcinoma xenotransplanted into nude mice. The purpose of this study was to evaluate the recently developed photosensitizing drug THOPP-MPEG for its efficacy as photosensitizer for LIFD and PDT of renal cell carcinoma.

[The prevention and treatment of experimental radiation injuries to the skin by using the Nucliderm-gel preparation].

Radiopreventive and radiotherapeutic efficacy of nuclyderm-gel was studied on tails of mice exposed to fractionated gamma-radiation of 90 Gy (15 + 30 + 45 Gy) and 75 Gy (45 + 30 Gy). Daily seven-day treatment with nuclyderm-gel prior to irradiation with increasing doses (15 + 30 + 45 Gy) and the subsequent continuous therapy were shown to delay and reduce skin reactions. Nuclyderm-gel was particularly effective when used therapeutically.

[Cell proliferation kinetics in sarcoma 37. I. The changes in the size of the cell and the nucleus over the generative cycle].

Using morhometric autoradiographic and cytophotometric methods, the author examined the changes in the size of the nucleus, and of the cell as well as of the ratio: surface of the nucleus (surface of the cytoplasma in sarcoma-37 ascitic variant in accordance with their position in the generative cycle. The cells with small sizes of the nucleus 30 microns 2 were not labelled with 3H-thymidine and were found mainly in Gi-phase of the cycle. The labelled cells with nuclear sizes of 40-60 microns 2 were at the S-phase of the cycle.