The Evolution of Colgate Total®: A New Era Stabilized by Nitrate and Phosphates.

Effective and accessible oral care strategies, like the use of a multi-benefit, antimicrobial toothpaste, are a key tool in preventive public health. For over 30 years, Colgate Total toothpastes have represented a gold standard in multi-benefit toothpastes to help fight bacteria and provide whole-mouth care. This review introduces the next generation of Colgate's research and development featuring stannous fluoride (SnF2) stabilized by nitrate and phosphates.

Oxidative stability of chelated Sn(II) at neutral pH: The critical role of NO ions.

Tin(II) compounds are versatile materials with applications across fields such as catalysis, diagnostic imaging, and therapeutic drugs. However, oxidative stabilization of Sn(II) has remained an unresolved challenge as its reactivity with water and dioxygen results in loss of functionality, limiting technological advancement. Approaches to slow Sn(II) oxidation with chelating ligands or sacrificial electron donors have yielded only moderate improvements.

Utility of saturation trends to predict successful weaning of nasal CPAP in very preterm neonates - A prospective study.

Background: There is no objective criteria to wean CPAP in preterm neonates. We aimed to assess the accuracy of 'saturation trends' to predict successful CPAP discontinuation.

Methods: We included very preterm neonates who required CPAP.

Changing Patterns of Organisms Causing Neonatal Sepsis and Their Antimicrobial Sensitivity Profile in a Tertiary Center - A Prospective Study.

Objective: To identify the profile of organisms causing neonatal sepsis and their antibiotic susceptibility pattern in recent years.

Methods: In this prospective study, authors included neonates with blood culture proven sepsis. Antibiotic resistance patterns that were identified were extended spectrum β-lactamase, AmpC β-lactamase and possible carbapenamase producer.

Reading the epitranscriptome of the human malaria parasite.

Epigenetic machinery has emerged as a central player in gene regulation and chromatin organization in Plasmodium spp. Epigenetic modifications on histones and their role in antigenic variation in P. falciparum are widely studied.