Publications by authors named "G Gouello"
Background: The global healthcare system has been overwhelmed by the Coronavirus disease-2019 (COVID-19). In order to mitigate the risk of spread of the virus, most elective surgical procedures have been cancelled especially during the lockdown periods. The purpose of this study was to assess the financial impact of the COVID outbreak due to the supposed reduced workload from our neurosurgery department in 2020.
View Article and Find Full Text PDFParkinson's disease is typically treated with oral dopamine replacement therapies. However, long-term use is complicated by motor fluctuations from intermittent stimulation of dopamine receptors and off-target effects. ProSavin, a lentiviral vector based gene therapy that delivers local and continuous dopamine, was previously shown to be well tolerated in a Phase I/II first-in-human study, with significant improvements in motor behavior from baseline at 1 year.
View Article and Find Full Text PDFArticle Synopsis
- Deep brain stimulation (DBS) targeting the subthalamic nucleus (STN) is an effective treatment for motor symptoms in patients with Parkinson's disease who do not respond to medication, but current imaging methods struggle to visualize the STN accurately.
- A new imaging technique, 3D-SPACE FLAIR at high magnetic fields, was developed and validated, showing greater consistency in locating the STN compared to the traditional T2-weighted imaging method.
- Patients whose DBS procedures were guided by the new imaging method experienced significantly greater improvements in their motor symptoms after one year compared to those whose procedures used the older imaging technique.
Study Objectives: To explore the influence of acute bilateral ventral intermediate thalamic nucleus (VIM) stimulation on sleep.
Design: Three consecutive full-night polysomnography recordings were made in the laboratory. After the habituation night, a random order for night ON-stim and OFF-stim was applied for the second and third nights.
Background: Decompressive craniectomy can be proposed in the management of severe traumatic brain injury. Current studies report mixed results, preventing any clear conclusions on the place of decompressive craniectomy in traumatology.
Methods: The objective of this retrospective study was to evaluate the results of all decompressive craniectomies performed between 2005 and 2011 for refractory intracranial hypertension after severe traumatic brain injury.