Publications by authors named "G Goldman"
can cause invasive pulmonary aspergillosis (IPA). Fungicidal azoles and fungistatic caspofungin (CAS) are the first- and second-line therapies, respectively, used to treat IPA. Treatment of with CAS or micafungin induces the production of the oxylipin 5,8-diHODE by the fungal oxygenase PpoA.
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- 53 isolates of Aspergillus section Nidulantes fungi were studied, revealing that 30 clinical isolates, including four from COVID-19 patients, were misidentified as the cryptic pathogen A. latus, which resulted from a hybridization event.
- The research showed that A. latus displays significant genetic diversity and that both parental subgenomes are actively expressed in clinical isolates, responding to different environmental conditions.
- Key differences in drug resistance and growth in oxidative stress were found between A. latus hybrids and related species, along with four features that could help in accurately identifying A. latus in the future.
Article Synopsis
- Fungal pathogens like Aspergillus fumeigatus show strain variation in their ability to cause disease, but it's unclear if non-pathogenic relatives like Aspergillus fischeri do as well.
- This study analyzed 16 strains of A. fischeri and found significant differences in their potential to cause harm, supported by immune response tests and mouse models.
- Additionally, genomic analyses revealed that these strains have greater genetic diversity, with specific metabolites linked to their varying levels of virulence, highlighting the importance of studying closely related non-pathogenic species to understand fungal pathogenicity.
Article Synopsis
- - Sporotrichosis, a common fungal infection in Latin America, poses a health risk to humans and pets, with drugs like itraconazole and amphotericin B facing increasing resistance.
- - Milteforan, a veterinary drug used for treating leishmaniasis in dogs, shows promise as an alternative treatment for sporotrichosis due to its fungicidal activity against resistant fungal strains.
- - The study indicates that milteforan not only reduces fungal load in human and mouse cells but also modulates immune response by lowering cytokine levels, suggesting its potential effectiveness against feline sporotrichosis.
Article Synopsis
- Aspergillus fumigatus causes the infection known as aspergillosis and uses asexual spores to infect hosts, but little is known about how it evades the immune system.
- In this study, researchers analyzed the conidial surface proteins of A. fumigatus and compared them to two non-pathogenic species, discovering 62 proteins unique to A. fumigatus.
- Testing null mutants for 42 genes revealed that deleting 33 of these genes affected the fungus's ability to resist immune responses, particularly highlighting a gene that influences the proinflammatory cytokine IL-1β, which is crucial for infection in a mouse model.