Publications by authors named "G Goehring"
Article Synopsis
- Upregulation of the TCL1A proto-oncogene is linked to various aggressive B-cell and T-cell cancers, but its mechanisms, especially in the nucleus, are not fully understood.
- Research showed that TCL1A influences lymphomagenesis in mouse models by altering nuclear organization and interacts with proteins that regulate the cell cycle and DNA repair, notably CDC20.
- High levels of TCL1A correlate with faster cell cycle transitions, increased chromosome missegregation, and aneuploidy, suggesting TCL1A disrupts normal cell cycle control, potentially leading to more aggressive forms of cancer.
Background: Gene expression can be influenced by DNA methylation 1) distally, at regulatory elements such as enhancers, as well as 2) proximally, at promoters. Our current understanding of the influence of distal DNA methylation changes on gene expression patterns is incomplete. Here, we characterize genome-wide methylation and expression patterns for ~ 13 k genes to explore how DNA methylation interacts with gene expression, throughout the genome.
View Article and Find Full Text PDFIndividuals with Fanconi anemia (FA) have a high risk of developing myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), yet the secondary somatic mutations lending to these malignancies remain to be further elucidated. We employed a next-generation sequencing myeloid neoplasia gene panel to determine the mutational spectrum of FA-related MDS/AML. Ten of 16 patients showed missense, nonsense, insertion or duplication mutations in 13 genes.
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