Publications by authors named "G Ginsberg"
Background And Aims: Glucagon-like peptide-1 receptor agonists (GLP1RAs) can cause delayed gastric emptying, raising concern for retained gastric contents (RGCs) during endoscopy and adverse anesthesia events. We aimed to determine associations between GLP1RA and endoscopy and anesthesia outcomes.
Methods: This single-center retrospective cohort study examined patients prescribed GLP1RA who underwent outpatient endoscopy stratified by exposure at the time of endoscopy.
1,4-Dioxane (DX), an emerging water contaminant, is classified as a Group 2B liver carcinogen based on animal studies. Understanding of the mechanisms of action of DX liver carcinogenicity is important for the risk assessment and control of this environmental pollution. Previous studies demonstrate that high-dose DX exposure in mice through drinking water for up to 3 months caused liver mild cytotoxicity and oxidative DNA damage, a process correlating with hepatic CYP2E1 induction and elevated oxidative stress.
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- The study investigates the relationship between systemic bile acids and the progression of Barrett's esophagus (BE), particularly their role in advancing stages that may lead to esophageal adenocarcinoma (EAC).
- It involved profiling serum bile acids in 141 subjects (both with and without BE) and examined how various factors, like diet and age, influenced bile acid levels, finding significant differences between non-BE and BE stages.
- Results indicate that higher levels of specific bile acids, especially cholic acid, are linked to advanced BE conditions and gene expression changes, suggesting that they may serve as potential biomarkers or targets for future therapeutic strategies.
Background: Deep learning (DL) is a new technology that can assist prenatal ultrasound (US) in the detection of congenital heart disease (CHD) at the prenatal stage. Hence, an economic-epidemiologic evaluation (aka Cost-Utility Analysis) is required to assist policymakers in deciding whether to adopt the new technology.
Methods: The incremental cost-utility ratios (CUR), of adding DL assisted ultrasound (DL-US) to the current provision of US plus pulse oximetry (POX), was calculated by building a spreadsheet model that integrated demographic, economic epidemiological, health service utilization, screening performance, survival and lifetime quality of life data based on the standard formula: US screening data were based on real-world operational routine reports (as opposed to research studies).