Publications by authors named "G Gillies"
Article Synopsis
- Sepsis leads to specific immune system changes, particularly the increase of myeloid-derived suppressor cells (MDSCs), which help control inflammation but can linger in those with ongoing critical illness.
- The study employs advanced techniques like Cellular Indexing of Transcriptomes and Epitopes by Sequencing to analyze MDSC types based on gene expression and biological functions.
- Findings reveal a new lineage and differentiation pathway for MDSCs following sepsis, emphasizing their variable responses related to patient outcomes and demonstrating their ability to change, contradicting the previous belief of a fixed lineage.
Purpose: Our objectives were to compare overall survival (OS) and pulmonary relapse between patients with metastatic Ewing sarcoma (EWS) at diagnosis who achieve rapid complete response (RCR) and those with residual pulmonary nodules after induction chemotherapy (non-RCR).
Patients And Methods: This retrospective cohort study included children under 20 years with metastatic EWS treated from 2007 to 2020 at 19 institutions in the Pediatric Surgical Oncology Research Collaborative. Chi-square tests were conducted for differences among groups.
This review focuses on the current understanding regarding lipid crystallisation at oil-water interfaces. The main aspects of crystallisation in bulk lipids will be introduced, allowing for a more comprehensive overview of the crystallisation processes within emulsions. Additionally, the properties of an emulsion and the impact of lipid crystallisation on emulsion stability will be discussed.
View Article and Find Full Text PDFAcute emergence of the intestinal pathobiome after postinjury pneumonia.
J Trauma Acute Care Surg
July 2024
Background: Previous preclinical studies have demonstrated sex-specific alterations in the gut microbiome following traumatic injury or sepsis alone; however, the impact of host sex on dysbiosis in the setting of postinjury sepsis acutely is unknown. We hypothesized that multicompartmental injury with subsequent pneumonia would result in host sex-specific dysbiosis.
Methods: Male and proestrus female Sprague-Dawley rats (n = 8/group) were subjected to either multicompartmental trauma (PT) (lung contusion, hemorrhagic shock, cecectomy, bifemoral pseudofracture), PT plus 2-hour daily restraint stress (PT/RS), PT with postinjury day 1 Pseudomonas aeruginosa pneumonia (PT-PNA), PT/RS with pneumonia (PT/RS-PNA), or naive controls.
Exosomal microRNA following severe trauma: Role in bone marrow dysfunction.
J Trauma Acute Care Surg
April 2024
Introduction: Severe trauma disrupts bone marrow function and is associated with persistent anemia and altered hematopoiesis. Previously, plasma-derived exosomes isolated after trauma have been shown to suppress in vitro bone marrow function. However, the cargo contained in these vesicles has not been examined.
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