Publications by authors named "G Giannone"
Article Synopsis
- * A study used an intermittently scanned continuous glucose monitoring (isCGM) device during surgery on five insulinoma patients to assess real-time glucose fluctuations for better surgical outcomes.
- * Results showed that isCGM effectively indicated complete tumor excision, with varying glucose responses based on pre-treatment, suggesting it could become a standard tool in insulinoma surgery if validated in larger studies.
Article Synopsis
- Morphogenesis involves creating stable structures from dynamic proteins, with a focus on how muscles anchor via integrin adhesions to handle contractile forces.
- The study reveals that actin polymerization creates membrane protrusions that enhance adhesion at muscle attachment sites in fruit flies, supporting strong integrin assembly.
- It shows that the shape and texture of cellular membranes, rather than their stiffness, play a key role in the development and stability of these integrin sites during embryonic growth.
Bilateral macronodular adrenocortical disease (BMAD) is an uncommon cause of Cushing's syndrome leading to bilateral macronodules. Isolated BMAD has been classified into three molecular groups: patients with ARMC5 alteration, KDM1A alteration, and patients without known genetic cause. The aim of this study was to identify by NGS, in a cohort of 26 patients with BMAD, the somatic alterations acquired in different nodules after macrodissection from patients with germline ARMC5 or KDM1A alterations and to analyze potential somatic alterations in a panel of five other genes involved in adrenal pathology (GNAS, PDE8B, PDE11A, PRKAR1A, and PRKACA).
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- Ovarian high-grade serous carcinoma (HGSC) begins in the fallopian tube, with precursor cells called p53 signatures developing into more advanced lesions (STIC) that lead to invasive cancer and metastasis in the body.
- Research revealed that late-stage HGSC samples have a higher ploidy (genomic content) compared to early-stage samples, suggesting significant genetic changes occur throughout the disease's progression.
- Analyzing tissue samples from patients, the study found that alterations in ploidy happen early in the cancer's development, indicating these genetic changes could be key to understanding the progression of HGSC from its initial formations to more advanced stages.