Publications by authors named "G Giannico"
Article Synopsis
- - The study developed a nomogram to predict the likelihood of pelvic lymph node metastases (ypN+) after neoadjuvant chemotherapy in nonmetastatic muscle-invasive bladder cancer patients, finding that ypN+ is linked to worse overall survival.
- - Data from 6,194 patients were analyzed, revealing that 22.8% of high-risk patients had ypN+, compared to only 8.0% in the low-risk group, with high-risk patients experiencing significantly shorter survival (36.1 vs. 74.0 months).
- - Key factors contributing to the nomogram included age, time from diagnosis to treatment, and the tumor’s histology and stage, making it a valuable tool for assessing risk
Article Synopsis
- Upper tract urothelial carcinoma (UTUC) presents diagnostic and treatment challenges, highlighting the need for new biomarkers for tumor detection.
- * In a study of 139 UTUC cases, Keratin 17 (KRT17) showed significantly higher expression in malignant tumors compared to normal tissue, particularly in noninvasive and invasive forms.
- * The KRT17 marker demonstrated strong sensitivity (91%) and specificity (69%) for distinguishing benign from malignant tumors, suggesting its potential utility in future diagnostic practices.
Clear cell adenocarcinoma (CCA) of the urinary tract is a rare malignancy and tumors involving the renal pelvis are notably sparse in the literature, with only 5 other patients reported. We present 5 patients, 4 women, and 1 man, with CCA of the renal pelvis. The age at presentation ranged from 29 to 81 years.
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- - Oncocytic renal neoplasms pose significant diagnostic challenges, yet are generally nonaggressive, prompting discussion about the necessity of differentiating emerging subtypes like eosinophilic solid and cystic renal cell carcinoma and others.
- - A survey of 63 urologic pathologists revealed that many encounter complex oncocytic tumors frequently, with 70% agreeing that eosinophilic solid and cystic renal cell carcinoma should be recognized as a distinct category, while opinions were more divided on other types.
- - Diagnostic approaches varied among pathologists, with 60% hesitant to diagnose oncocytoma through needle biopsies, and a near split on the routine use of immunohistochemistry; common genetic testing was
Article Synopsis
- * The survey received an 85% response rate from 98 uropathologists, revealing strong agreement on distinguishing between luminal and basal UC types, but varied opinions on the importance of certain genetic tests like FGFR3 and TERT promoter mutations.
- * Most uropathologists acknowledged the aggressive nature of tumors with micropapillary features and favored further evaluation and specific molecular testing for aggressive subtypes, indicating a need for improved consensus in UC classification and treatment strategies.