Publications by authors named "G Giancola"
For decades, retinoids have been considered the gold standard of treatment for a variety of skin conditions.1,2 As the bioavailable form of vitamin A, retinoic acid has demonstrated the ability to reduce skin discoloration, stimulate collagen production, reduce rhytids, improve acne, and uneven skin texture.3,4 Retinoic acid is a potent drug with high bioavailability.
View Article and Find Full Text PDFBackground: Effective anti-aging treatments are an unmet consumer need.
Aim: Ex vivoand clinical tests have evaluated the efficacy of a topical facial serum containing a proprietary blend of neuropeptides, proteins, amino acids, and marine extracts on aged skin.
Methods: In the ex vivo study the facial serum was compared to a commercially marketed face serum and to an untreated control on skin explants using microrelief, smoothness, and epidermal thickness endpoints.
Background: In Cushing's syndrome (CS), chronic glucocorticoid excess (GC) and disrupted circadian rhythm lead to insulin resistance (IR), diabetes mellitus, dyslipidaemia and cardiovascular comorbidities. As undifferentiated, self-renewing progenitors of adipocytes, mesenchymal stem cells (MSCs) may display the detrimental effects of excess GC, thus revealing a promising model to study the molecular mechanisms underlying the metabolic complications of CS.
Methods: MSCs isolated from the abdominal skin of healthy subjects were treated thrice daily with GCs according to two different regimens: lower, circadian-decreasing (Lower, Decreasing Exposure, LDE) persistently higher doses (Higher, Constant Exposure, HCE), aimed at mimicking either the physiological condition or CS, respectively.
Background: Amino acids are major components of skin's natural moisturizing factors and play a role in regulating skin hydration and skin pH.
Objective: This research examines a proprietary amino acid complex technology (AAComplex) designed to help reduce skin irritation and repair skin damage.
Methods: In- vitro Scratch Assay HaCaT cells are scratched, and the wounds are imaged at different time points until the closure of the scratch wound is detected.
Article Synopsis
- Dysnatremia, which includes both hyponatremia and hypernatremia, is prevalent among hospitalized COVID-19 patients and can negatively impact their health outcomes.
- In a study of 117 COVID-19 inpatients, 26.5% had low sodium levels at admission, while 6.8% had high sodium levels, with some patients experiencing both conditions during their hospital stay.
- Lower sodium levels correlated with higher inflammation markers, and both hypernatremia and fluctuating sodium levels were linked to longer hospital stays and increased need for ICU care, highlighting the importance of managing sodium levels in these patients.