Publications by authors named "G Giampaglia"
Objectives: Benign prostatic hyperplasia (BPH) is a common urological condition affecting aging men worldwide. Among the treatment options available for BPH, transurethral resection of the prostate (TURP) is the gold-standard invasive intervention. To reduce the TURP-related non-negligible morbidity, loss-of-ejaculation rate, hospitalization, blood loss and catheterization time several laser techniques have been developed, such as the Thulium Laser Enucleation of the Prostate (ThuLEP).
View Article and Find Full Text PDFRenal cell carcinoma (RCC) remains a formidable diagnostic challenge, especially in the context of small renal masses. The quest for non-invasive screening tools and biomarkers has steered research towards liquid biopsy, focusing on microRNAs (miRNAs), exosomes, and circulating tumor cells (CTCs). MiRNAs, small non-coding RNAs, exhibit notable dysregulation in RCC, offering promising avenues for diagnosis and prognosis.
View Article and Find Full Text PDFWhich inflammatory marker, between systemic immune-inflammation index and neutrophil to eosinophil ratio, is associated with Peyronie's disease and are there any implications for a better understanding of its mechanisms?
Basic Clin Androl
December 2023
Article Synopsis
- Peyronie's disease, affecting 9% of men, involves inflammation leading to fibrosis and is associated with pain and erectile dysfunction; there's a need for better understanding of its onset and progression.
- Researchers created a systemic immune-inflammation index (SII) and identified a neutrophil-to-eosinophil ratio (NER) as potential biomarkers to help evaluate the disease's inflammation.
- A study comparing 49 men with Peyronie's to 50 controls found significant differences in NER and eosinophil counts, with a higher prevalence of hypercholesterolemia, hyperglycemia, and hypertension in patients; the NER was most effective at distinguishing between groups.
Urinary tract infections represent a common and significant health concern worldwide. The high rate of recurrence and the increasing antibiotic resistance of uropathogens are further worsening the current scenario. Nevertheless, novel key ingredients such as D-mannose, chondroitin sulphate, hyaluronic acid, and -acetylcysteine could represent an important alternative or adjuvant to the prevention and treatment strategies of urinary tract infections.
View Article and Find Full Text PDFIntroduction: Bacterial prostatitis (BP) is a common prostatic infection characterized by a bimodal distribution in young and older men, with a prevalence between 5-10% among all cases of prostatitis and a high impact on quality of life. Although the management of bacterial prostatitis involves the use of appropriate spectrum antibiotics, which represent the first choice of treatment, a multimodal approach encompassing antibiotics and nutraceutical products in order to improve the efficacy of chosen antimicrobial regimen is often required.
Objective: To evaluate the efficacy of Flogofilm in association with fluoroquinolones in patients with chronic bacterial prostatitis (CBP).