Publications by authors named "G Geslain"
Introduction: In children, respiratory distress due to upper airway obstruction (UAO) is a common complication of extubation. The quantitative cuff-leak test (qtCLT) is a simple, rapid and non-invasive test that has not been extensively studied in children. The objective of the ongoing study whose protocol is reported here is to investigate how well the qtCLT predicts UAO-related postextubation respiratory distress in paediatric intensive care unit (PICU) patients.
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- A study evaluated the effectiveness of the BioFire Pneumonia plus Panel, a rapid-multiplex PCR assay, in diagnosing lower-respiratory-tract infections in critically ill pediatric patients compared to traditional culturing methods.
- It included 36 patients with varying types of pneumonia and found that the PCR assay had high sensitivity (92%) and specificity (95%), with a notable agreement between the two methods (κ = 0.74).
- The PCR assay also provided faster results (about 3.9 hours) than the reference method (about 60.5 hours), potentially leading to better-targeted antibiotic treatments and reduced unnecessary antibiotic use.
Background: Sickle cell disease (SCD) is one of the most frequent inherited diseases in the world. Over the last decades, in high-income countries, an important decrease in mortality have been observed due to the improvement of care. However, children with SCD can become critically ill and require admission in Pediatric Intensive Care Units (PICU).
View Article and Find Full Text PDFUsing whole-genome sequencing, we characterized Escherichia coli strains causing early-onset sepsis (EOS) in 32 neonatal cases from a 2019-2021 prospective multicenter study in France and compared them to E. coli strains collected from vaginal swab specimens from women in third-trimester gestation. We observed no major differences in phylogenetic groups or virulence profiles between the 2 collections.
View Article and Find Full Text PDFWe report fatal meningitis in 2 neonates in France caused by Shiga toxin 1-producing Escherichia coli. Virulence factors capsular K1 antigen and salmochelin were present in both strains, potentially representing a new hybrid pathotype. Clinicians should remain aware of emerging pathotypes and design therapeutic strategies for neonatal E.
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