The effect of coal-fired power plants on ambient air quality in Mpumalanga province, South Africa, 2014-2018.

Several coal-fired power plants (CFPPs) were built in South Africa, mainly in the central Mpumalanga Province, due to an increase in the demand for Eskom, the national power utility, to keep up with socio-economic growth. The CFPPs, of which 90% are owned by Eskom, generate a significant share of the country's electricity but contribute to the air pollution experienced in the country. The paper discusses sulphur dioxide (SO2), nitrogen dioxide (NO2) and particulate matter of size less than 10 micrometre (μm) in diameter (PM10), using data from 2014 to 2018.

A Unifying Hypothesis for the Genome Dynamics Proposed to Underlie Neuropsychiatric Phenotypes.

The sheer number of gene variants and the extent of the observed clinical and molecular heterogeneity recorded in neuropsychiatric disorders (NPDs) could be due to the magnified downstream effects initiated by a smaller group of genomic higher-order alterations in response to endogenous or environmental stress. Chromosomal common fragile sites (CFS) are functionally linked with microRNAs, gene copy number variants (CNVs), sub-microscopic deletions and duplications of DNA, rare single-nucleotide variants (SNVs/SNPs), and small insertions/deletions (indels), as well as chromosomal translocations, gene duplications, altered methylation, microRNA and L1 transposon activity, and 3-D chromosomal topology characteristics. These genomic structural features have been linked with various NPDs in mostly isolated reports and have usually only been viewed as areas harboring potential candidate genes of interest.

Seasonal variations of natural organic matter (NOM) in surface water supplied to two coal-fired power stations.

Global issues such as pollution and global warming have resulted in changes in water characteristics over the past 20 years. Natural organic matter (NOM) which is a major component in water systems has shown an increase globally. This increase in NOM concentration has negatively affected both water treatment processes and drinking water quality.

Lu-Dotatate plus long-acting octreotide versus high‑dose long-acting octreotide in patients with midgut neuroendocrine tumours (NETTER-1): final overall survival and long-term safety results from an open-label, randomised, controlled, phase 3 trial.

Background: The primary analysis of the phase 3 NETTER-1 trial showed significant improvement in progression-free survival with Lu-Dotatate plus long-acting octreotide versus high-dose long-acting octreotide alone in patients with advanced midgut neuroendocrine tumours. Here, we report the prespecified final analysis of overall survival and long-term safety results.

Methods: This open-label, randomised, phase 3 trial enrolled patients from 41 sites in eight countries across Europe and the USA.