Publications by authors named "G Georges"
Article Synopsis
- - A study compared the outcomes of autologous hematopoietic stem cell transplantation (AHSCT) using unmodified peripheral blood stem cells (PBSC) with maintenance therapy (mycophenolate mofetil) versus a previously studied method that involved CD34+ selected PBSC in patients with diffuse systemic sclerosis (SSc).
- - In this trial involving 20 high-risk SSc patients, the 5-year overall survival (OS) was estimated at 85%, and event-free survival (EFS) was 75%, indicating promising results with this new approach.
- - The research highlighted a potential risk factor for poor outcomes in patients undergoing AHSCT: having a low estimated glomerular filtration rate (
We present a detailed mass spectrometric analysis of three 2 + 1 T-cell bispecific monoclonal antibodies (TCB mAbs), where an unexpected +15.9950 Da mass shift in tryptic peptides was observed. This modification was attributed to the occurrence of 5R-hydroxylysine (Hyl) using a hybrid LC-MS/MS molecular characterization and CRISPR/Cas9 gene deletion approach.
View Article and Find Full Text PDFBackground: The single-inhaler triple combination of beclometasone dipropionate, formoterol fumarate, and glycopyrronium (BDP/FF/G) is available for maintenance therapy of chronic obstructive pulmonary disease (COPD). Cardinal features of COPD are lung hyperinflation and reduced exercise capacity. TRIFORCE aimed to evaluate the effect of BDP/FF/G on lung hyperinflation and exercise capacity in patients with COPD.
View Article and Find Full Text PDFPatient Selection and End Point Definitions for Decongestion Studies in Acute Decompensated Heart Failure: Part 2.
J Soc Cardiovasc Angiogr Interv
August 2023
Article Synopsis
- Congestion is a key symptom of acute decompensated heart failure (ADHF) and often persists despite initial treatment, leading to poorer patient outcomes.* -
- There is currently no standard definition for what constitutes successful decongestion, which complicates assessment and treatment planning.* -
- The review suggests a new 4-class grading system for congestion and decongestion endpoints to improve consistency in ADHF research and patient care.*
Patient Selection and End Point Definitions for Decongestion Studies in Acute Decompensated Heart Failure: Part 1.
J Soc Cardiovasc Angiogr Interv
August 2023
Article Synopsis
- * Persistent congestion during increased diuretic treatment is an indicator of poor prognosis, leading to the development of new device-based therapies aimed at improving outcomes.
- * The review identifies patient risk factors for severe congestion related to their past medical history, the extent of their congestion, how well they respond to diuretics, and their kidney function, while also outlining criteria for including high-risk patients in future studies.