Publications by authors named "G George"
Post-neoadjuvant therapy (post-NAT) and post-surgical circulating tumor DNA (ctDNA) risk stratification may enhance the management of patients with locally advanced rectal cancer (LARC). In this study, we assessed the prognostic value of ctDNA-based MRD detection in LARC patients using a personalized, tumor-informed ctDNA assay. Plasma samples from LARC patients (N = 30) were analyzed retrospectively using the Signatera™ assay.
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- Human parechoviruses (HPeVs) are significant causes of central nervous system infections in neonates, with a study conducted in Alberta from 2014 to 2019 focusing on HPeV-3 and the emerging HPeV-5 strains.
- Among the 18,882 cerebrospinal fluid samples tested, 56 were positive for HPeVs, with a higher prevalence in 2016 and a notable spike in infections during late summer to fall.
- The study found differences in mean ages of infection (18 days for HPeV-5 vs. 26 days for HPeV-3), and genetic sequencing suggested similarities with a recombinant strain identified in Australia, highlighting the need for ongoing research
Although V600E mutations are common in solid tumors and select hematologic neoplasms, they are reported less frequently in myeloid malignancies. Of the cases of V600E-mutant acute myeloid leukemia (AML) that have been described, most display monocytic morphology and concurrent rearrangement. Strikingly, all cases have been associated with poor survival.
View Article and Find Full Text PDFEarly-onset colorectal cancer (EOCRC), recognized as a distinct subgroup with an increased incidence over the past two decades, characterized by its aggressive nature and potentially unique molecular factors that differentiate it from traditional colorectal cancer (CRC). In this study, we investigated differentially expressed genes in a young-CRC patient using paired-end mRNA-sequencing. Validation of target genes through qRT-PCR highlighted a significant increase in SERPINA3 levels in EOCRC, representing a novel finding.
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- The study investigates how post-traumatic stress symptoms (PTSS) impact treatment outcomes like depression, anxiety, and overall functioning among patients in partial hospital programs (PHP).
- A total of 1,298 adults participated, with linear regression analyses showing that those with severe PTSS had poorer improvement in mental health compared to those without trauma history or less severe symptoms.
- The findings suggest that severe PTSS could predict treatment outcomes in acute psychiatric settings, highlighting the importance of trauma-informed care despite limitations in generalizability due to the study's design.