Publications by authors named "G Gentilomi"
Article Synopsis
- * Certain compounds showed strong inhibitory effects (13.8-90.1 µM) without harming human epithelial or red blood cells, with the most effective derivative undergoing further testing for its anti-biofilm properties and impact on methicillin-resistant bacteria.
- * Analysis included a structure-activity relationship study to identify key structural features for antibacterial effectiveness, alongside molecular modeling that revealed how the active compound inhibits the FtsZ protein crucial for bacterial cell division.
Article Synopsis
- This research focuses on developing a multilayer biomaterial patch that incorporates LTX-109, an antimicrobial peptide aimed at treating bacterial skin infections.
- The patch has a layered structure: a protective outer layer, a medicated middle layer with LTX-109, and a bottom layer designed to control the release of the peptide.
- Extensive testing shows the patch effectively promotes wound healing by controlling moisture, allowing oxygen flow, being biodegradable and biocompatible, and maintaining the antibacterial properties of LTX-109.
Snail secretion is a complex mixture of several components, including proteins, glycoproteins, mucopolysaccharides and smaller molecules. Its growing use in nutraceutical, cosmetic and biomedical applications, as well as a component of edible and green packaging to replace chemical plasticizer, implies more affordable and sustainable extraction methods. We chose four extracts obtained from Cornu aspersum snails, different by origin, extraction medium (namely, citric acid, lactic acid or none) and additives and we performed a series of characterizations including the SDS-page, the measure of pH and density, the evaluation of dry matter and of protein content, supported by structural determinations by means of UV-visible and infrared spectroscopy, X-Rays diffraction and thermogravimetric measurements.
View Article and Find Full Text PDFBackground: Arbutus unedo L. is a wild tree of Mediterranean regions used as food and in traditional medicine and important for afforestation programs. There is no detailed information available on the variation of A.
View Article and Find Full Text PDFMetal-organic frameworks (MOFs) are a class of crystalline porous materials with outstanding physical and chemical properties that make them suitable candidates in many fields, such as catalysis, sensing, energy production, and drug delivery. By combining MOFs with polymeric substrates, advanced functional materials are devised with excellent potential for biomedical applications. In this research, Zeolitic Imidazolate Framework 8 (ZIF-8), a zinc-based MOF, was selected together with cellulose, an almost inexhaustible polymeric raw material produced by nature, to prepare cellulose/ZIF-8 composite flat sheets via an in-situ growing single-step method in aqueous media.
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