Publications by authors named "G Gener"
Article Synopsis
- - The study aimed to evaluate the effectiveness of patch tests (PTs) in identifying drugs causing non-immediate cutaneous adverse drug reactions (NICADRs) by comparing readings at days 3 (D3) and 4 (D4).
- - Findings revealed that only 13.7% of patients tested positive on D3, while 24.9% tested positive on D4, highlighting a significant increase in sensitivity with the later reading (p < 0.0001).
- - The research concluded that an additional reading at D4 improves the detection of culprit drugs in NICADRs, suggesting further investigations to confirm these results and explore the cost-effectiveness of this testing approach.
In Situ Patch Test and Repeated Open Application Test for Fixed Drug Eruption: A Multicenter Study.
J Allergy Clin Immunol Pract
February 2024
Background: Few studies have evaluated allergy workup in fixed drug eruption (FDE) in a large population.
Objective: To evaluate the sensitivity of a standardized allergy workup for diagnosing the cause of FDE, with a focus on in situ repeated open application tests (ROATs).
Methods: In a retrospective multicenter study, we analyzed the practice of conducting a complete allergy workup for the etiological diagnosis of FDE.
Objective: To analyse the clinical characteristics and sensitivity of an essential oil patch test series (EOS) in patients sensitized to their own essential oils (EOs).
Method: We analysed the clinical data and patch test results obtained with the European baseline series (BSE) and an EOS, as well as the mode of use of EOs, through a questionnaire included in the patient file.
Results: The study included 42 patients (79% women, average age 50 years) with allergic contact dermatitis (ACD), 8 patients required hospitalization.
Skin Testing and Drug Provocation Tests in Epidermal Necrolysis: A French Experience.
J Allergy Clin Immunol Pract
December 2022
Background: There are limited data on the use of skin testing, other than patch testing, and challenges in the evaluation of epidermal necrolysis (EN), including Stevens-Johnson syndrome and toxic epidermal necrolysis.
Objective: To report a French multicenter experience in skin testing and challenges in EN, and investigate the factors associated with tests' positivity.
Methods: All patients who were evaluated by patch tests (PTs), skin prick tests, intradermal tests (IDTs), or drug provocation tests (DPTs) for EN between 2010 and 2020 were retrospectively included through 2 French drug reaction networks.
Background: Patch tests (PTs) with two readings have been used for decades to identify the culprit drug in nonimmediate cutaneous adverse drug reactions (NICADRs), followed more recently by late reading of intradermal tests (IDTs). Some teams tend to perform PTs with only one reading before IDTs or even directly perform IDTs.
Objectives: To evaluate the relevance of a late PT reading on day 4 (D4) in NICADRs.