Mechanisms of digoxin-amiodarone interaction in the rat.

Amiodarone and digoxin are often used in combination and clinical experience suggests that amiodarone may increase serum digoxin levels and toxicity. We have investigated the influence of amiodarone on digoxin pharmacokinetics and tissue distribution in the rat. Forty-nine rats were injected with 10 mg/kg amiodarone sc three times a day for 7 days, while 49 others were injected with saline only.

Plasma and tissue levels of digoxin in the rat following pretreatment with verapamil.

Verapamil and digoxin are frequently used in combination, and clinical experience suggests that verapamil may increase digoxin toxicity. We have investigated the influence of verapamil on digoxin pharmacokinetics in the rat. Rats were injected with 10 mg/kg verapamil s.

Verapamil and digoxin: interactions in the rat.

Verapamil and digoxin are often used in combination and clinical experience suggests that verapamil may increase digoxin toxicity. We have explored the effects of verapamil upon digoxin induced tachyarrhythmias and have undertaken a preliminary study of the influence of verapamil on digoxin pharmacokinetics in the rat. Anesthetized rats received 20 mg/kg of digoxin intraperitoneally followed by verapamil i.