Publications by authors named "G Gaudenzi"
Medullary thyroid carcinoma (MTC), a rare neuroendocrine tumor comprising 3-5% of thyroid cancers, arises from calcitonin-producing parafollicular C cells. Despite aggressive behavior, surgery remains the primary curative treatment, with limited efficacy reported for radiotherapy and chemotherapy. Recent efforts have explored the pathogenetic mechanisms of MTC, identifying it as a highly vascularized neoplasm overexpressing pro-angiogenic factors.
View Article and Find Full Text PDFNeuroendocrine neoplasms (NENs) originating in the gastroenteropancreatic (GEP) tract are rare tumors often associated with significant metabolic disturbances and nutritional challenges. This review explores the intricate relationship between nutritional status and the development, progression, and prognosis of GEP-NENs. Through an extensive literature search encompassing studies up to April 2024, we examined various factors, including obesity, malnutrition, metabolic syndrome and type 2 diabetes mellitus, and their roles in the development and progression of GEP-NENs.
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- Tissue engineering has progressed with 3D bioprinting, but challenges like creating biocompatible bioinks persist, especially with hydrogels that mimic natural tissue but have weak mechanical properties.
- This study examines various alginate and gelatin hydrogel compositions to assess cell metabolic activity beyond basic cell viability, aiming to create viable 3D structures.
- Results show that the assessment methods (live/dead staining and ATP assay) yield different insights into cell viability and activity, highlighting the need for both approaches in evaluating cell-laden hydrogels.
Exploring the multifaceted antitumor activity of axitinib in lung carcinoids.
Front Endocrinol (Lausanne)
July 2024
Article Synopsis
- Lung carcinoids (LCs) are rare neuroendocrine tumors in the lungs, representing 20-25% of neuroendocrine tumors and 1-2% of lung cancers, making anti-angiogenic therapies like axitinib (AXI) potential treatment options.
- In a study, three LC cell lines were treated with AXI to assess its long-term effects, focusing on cell cycle changes, apoptosis, and mechanisms like senescence and mitotic catastrophe.
- Results indicated that AXI effectively inhibits tumor growth by causing indirect DNA damage, but its efficacy may decrease if DNA damage is repaired, emphasizing the importance of DNA damage in its therapeutic action.