Publications by authors named "G Garrone"
Article Synopsis
- A study was conducted to analyze neurogenic bladder function in patients who underwent different surgical repairs for myelomeningocele (MMC), focusing on those who received in-utero surgery versus postnatal treatment.
- The research utilized a database created from 2018 to 2023 to track bladder function outcomes, complications like hydronephrosis, and treatment effectiveness across varied MMC repair methods.
- Preliminary findings suggest that in-utero MMC closure does not lead to improved bladder function compared to postnatal surgical options, contrasting previous beliefs based on the MOMS study data.
Introduction: In-utero myelomeningocele repair is the gold standard treatment after the publication of the MOMS trial. We have performed a retrospective analysis from our prospective in-utero myelomeningocele closure database (started in 2011), and selected only patients with the incontinent bladder pattern according to the Leal da Cruz categorization (Leal da Cruz, et al. J Urol 2015) to review mid-term clinical outcomes.
View Article and Find Full Text PDFIntroduction: After 5 years experience with the GUD (glandular urethral disassembly) technique for distal hypospadias, we present the GUDplay technique, incorporating Thiersch-Duplay tubularization of the plate till the coronal area, disassembling the glans aggressively and refurbishing the glans.
Methods: We defined the urethral plate and designed an inverted Y incision to open the glans in two wings. The glans was entirely detached from the corpora to gain a great mobility that allowed minor cranial mobilization of the urethra and caudal rotation of the wings.
Introduction: The Macedo ileal catheterizable channel was published in 2000 and consists of an enterocystoplasty with a catheterizable channel that precludes the need of the appendix for the efferent channel. After 25 years of experience with this technique, we decided to review our experience in a select subgroup of cases performed and followed exclusively by the author in a non-teaching hospital facility after the latest modifications of the procedure.
Materials And Methods: Since 2008, we have refined our technique with the following modifications: small skin transverse incision instead of longitudinal one, with a semicircular flap for further stoma creation in the midline and importantly the scissors maneuver.
Article Synopsis
- - Spinal muscular atrophy (SMA) is caused by mutations in the SMN1 gene, leading to decreased SMN protein levels, and Nusinersen is the first approved treatment that enhances functional SMN production from the SMN2 gene.
- - A study used high-resolution mass spectrometry to analyze cerebrospinal fluid from ten SMA type 3 patients, measuring changes in the proteome and metabolome before treatment and after two years to identify potential biomarkers for treatment response.
- - Results showed 26 proteins with significant expression changes, including markers indicating treatment efficacy, and indicated notable shifts in amino acid utilization, highlighting the potential of cerebrospinal fluid profiling as a biomarker for monitoring treatment effects in SMA type