Publications by authors named "G Galindo-Rodriguez"
Article Synopsis
- Microbial cell factories are being explored for producing high-value natural products sustainably, but recovering these products poses a major cost challenge.
- This study developed new 3D-printed hydrophobic adsorbents using benzyl methacrylate (BEMA) and butyl methacrylate (BUMA) as monomers, optimizing their pore structure with various porogens.
- The most effective adsorbent (BEMA40) demonstrated comparable taxadiene recovery to commercial options, showing that 3D printing can create customizable materials that enhance product recovery in microbial cultivation processes.
recovery of taxadiene using solid adsorption in cultivations with .
Prep Biochem Biotechnol
January 2024
In this study, an engineered strain of was used to produce taxadiene, a precursor in the biosynthetic pathway of the anticancer drug paclitaxel. Taxadiene was recovered with the polymeric adsorbent Diaion © HP-20. Here we tested two bioreactor configurations and adsorbent concentrations to maximize the production and recovery of taxadiene.
View Article and Find Full Text PDFBackground: 3D printing is revolutioning many industrial sectors and has the potential to enhance also the biotechnology and bioprocessing fields. Here, we propose a new flexible material formulation to 3D print support matrices with complex, perfectly ordered morphology and with tuneable properties to suit a range of applications in bioprocess engineering.
Findings: Supports were fabricated using functional monomers as the key ingredients, enabling matrices with bespoke chemistry, such as charged groups, chemical moieties for further functionalization, and hydrophobic/hydrophilic groups.
Background: Asthma patients show lower exercise tolerance.
Objective: Assessment of functional capacity in children with asthma.
Methods: Girls and boys from 6 to 17 years old were included in two groups: asthmatic patients and healthy subjects.
Do immunoglobulin G and immunoglobulin E anti-l-asparaginase antibodies have distinct implications in children with acute lymphoblastic leukemia? A cross-sectional study.
Rev Bras Hematol Hemoter
January 2017
Background: l-Asparaginase is essential in the treatment of childhood acute lymphoblastic leukemia. If immunoglobulin G anti-l-asparaginase antibodies develop, they can lead to faster plasma clearance and reduced efficiency as well as to hypersensitivity reactions, in which immunoglobulin E can also participate. This study investigated the presence of immunoglobulin G and immunoglobulin E anti-l-asparaginase antibodies and their clinical associations.
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