Results of genotoxicity testing of theophylline on bacteria and two lines of mammalian cells.

In study of the genotoxic effects of theophylline, this substance was subjected to a series of tests. Its potential mutagenicity was followed at the level of both bacteria and mammalian cells. The capacity of the substance to damage human DNA was determined by the so-called DNA inhibition test and by the method of alkaline elution of DNA.