Publications by authors named "G GIULIANI"
Background: Neuroimaging studies have shown that hypothalamic/thalamic nuclei and other distant brain regions belonging to complex cerebral networks are involved in cluster headache (CH). However, the exact relationship between these areas, which may be dependent or independent, remains to be understood. We investigated differences in resting-state functional connectivity (FC) between brain networks and its relationship with the microstructure of the hypothalamus and thalamus in patients with episodic CH outside attacks and healthy controls (HCs).
View Article and Find Full Text PDFBackground: The complex relationship among sleep, exercise, and the gut microbiome presents a unique opportunity to improve health and wellness. Here, we conducted the first large-scale investigation into the influence of a novel elite athlete-derived probiotic, consisting of a multi-strain Lactobacillus consortium, on sleep quality, exercise recovery, and gut microbiome composition in both elite athletes (n = 11) and the general population (n = 257).
Results: Our two-phase study design, which included an open-label study followed by a controlled longitudinal study in a professional soccer team, allowed us to identify key interactions between probiotics, the gut microbiome, and the host.
Sorting grids to exclude the juveniles of species targeted by bottom trawl fisheries from the catch are among the most promising solutions to reduce discards. We tested a two-sections Juveniles' Sorting Grid (JSG) in a Mediterranean fisheries restricted area. First, we provided information on the vitality of individuals escaping from the JSG bars during towing, by analysing underwater footage.
View Article and Find Full Text PDFArticle Synopsis
- High-dimensional technologies like CyTOF imaging mass cytometry (IMC) analyze the spatial arrangement of cancer and immune cells in tumor samples before immunotherapy, providing insights into their organization in the tumor microenvironment (TME).
- A new model developed using IMC data from melanoma patients undergoing ICI therapy reveals that the spatial relationships between activated CD8 T cells, macrophages, and melanoma cells significantly influence tumor growth and patient outcomes.
- Key findings highlight that the initial spatial configuration of these immune cells predicts tumor progression, with features like the co-clustering of activated CD8 T cells and macrophages being critical, despite variations during treatment.
Article Synopsis
- The study focuses on improving the understanding and identification of molecular glue substrates related to the E3 ligase receptor cereblon (CRBN), commonly used in clinical degraders.* -
- Researchers engineered human CRBN constructs for efficient production in E. coli, achieving a balance between high binding activity and production ease.* -
- The team developed an "Enamine focused IMiD library" for high-throughput screening, successfully identifying effective binders and laying the groundwork for future CRBN glue discoveries.*