EFFECT OF FOLLOW-UP OF ASTHMATIC CHILDREN IN PNEUMOPEDIATRICS ON DISEASE CONTROL.

Introduction: The pneumopediatrics consultation started at CHU-MEL in 2018; follow-up of asthmatic children is a major focus.

Objective: To assess the impact of follow-up on asthma disease control.

Method: This was a prospective cohort study with descriptive and analytical aims from October 2019 to October 2021.

IgG acquisition against PfEMP1 PF11_0521 domain cassette DC13, DBLβ3_D4 domain, and peptides located within these constructs in children with cerebral malaria.

The Plasmodium falciparum erythrocyte-membrane-protein-1 (PF3D7_1150400/PF11_0521) contains both domain cassette DC13 and DBLβ3 domain binding to EPCR and ICAM-1 receptors, respectively. This type of PfEMP1 proteins with dual binding specificity mediate specific interactions with brain micro-vessels endothelium leading to the development of cerebral malaria (CM). Using plasma collected from children at time of hospital admission and after 30 days, we study an acquisition of IgG response to PF3D7_1150400/PF11_0521 DC13 and DBLβ3_D4 recombinant constructs, and five peptides located within these constructs, specifically in DBLα1.

[Mite sensitization in children followed for respiratory allergy in a tropical African environment in Cotonou, Benin].

Introduction: In tropical Africa, allergies are not well documented. The objective of this work was to evaluate, by two methods, the sensitization to mites in children followed for respiratory allergy.

Methods: Skin prick-test and IgE assay by REAST test with 3 mites: Dermatophagoides pteronyssinus (D.

Proteomic analysis of Plasmodium falciparum parasites from patients with cerebral and uncomplicated malaria.

Plasmodium falciparum is responsible of severe malaria, including cerebral malaria (CM). During its intra-erythrocytic maturation, parasite-derived proteins are expressed, exported and presented at the infected erythrocyte membrane. To identify new CM-specific parasite membrane proteins, we conducted a mass spectrometry-based proteomic study and compared the protein expression profiles between 9 CM and 10 uncomplicated malaria (UM) samples.